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  1. SCCHN is the sixth most common cancer worldwide. Locally advanced SCCHN continues to be a therapeutic challenge with high rates of morbidity and mortality and a low cure rate. Despite the apparent impact of SC...

    Authors: Kun Kim, Mayur M Amonkar, Daniel Högberg and Frida Kasteng
    Citation: Head & Neck Oncology 2011 3:47
  2. Treatment of laryngeal cancers, may include surgery, radiotherapy, chemotherapy, or a combination. Total laryngectomy (TL) has been the standard surgical treatment. Partial laryngectomy procedures were perform...

    Authors: Bożena Wiskirska-Woźnica, Małgorzata Leszczyńska, Świdziński, Hanna Czerniejewska, Joanna Jackowska and Szyfter Witold
    Citation: Head & Neck Oncology 2011 3:46
  3. Reconstruction of large mandiblular defects following ablative oncologic surgery could be done by using vascularized bone transfer or, more often, primarily with simultaneous or delayed bone grafting, using lo...

    Authors: Harald Essig, Majeed Rana, Horst Kokemueller, Constantin von See, Martin Ruecker, Frank Tavassol and Nils-Claudius Gellrich
    Citation: Head & Neck Oncology 2011 3:45
  4. Oral cancer is the sixth most common malignancy worldwide with a mortality rate that is higher than many other cancers. Death usually occurs as a result of local invasion and regional lymph node metastases. De...

    Authors: Nyla Dil and Abhijit G Banerjee
    Citation: Head & Neck Oncology 2011 3:44
  5. Recent progress in ICG (indocyanine green) fluorescence imaging has provided a means by which we can detect sentinel lymph nodes (SLNs) without the risk of exposing patients to radiation. Neck metastasis is th...

    Authors: Junkichi Yokoyama, Shin Ito, Shinichi Ohba, Mitsuhisa Fujimaki and Katsuhisa Ikeda
    Citation: Head & Neck Oncology 2011 3:42
  6. Traditionally, in the United Kingdom and Europe the surgeon was generally not troubled by litigation from patients presenting as elective as well as emergency cases, but this aspect of custom has changed. Liti...

    Authors: Waseem Jerjes, Jaspal Mahil and Tahwinder Upile
    Citation: Head & Neck Oncology 2011 3:41
  7. Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. In addition to the disease's basic epidemiology and pathology, we review some current disc...

    Authors: Kimberley Ho, Helen Lin, David K Ann, Peiguo G Chu and Yun Yen
    Citation: Head & Neck Oncology 2011 3:40
  8. Cancer of the oral cavity is the sixth most common malignancy reported worldwide and one with the highest mortality rate among all malignancies. There is a paucity of reliable diagnostic methods to detect earl...

    Authors: Ravi Mehrotra, Sanjay Mishra, Mamta Singh and Mangal Singh
    Citation: Head & Neck Oncology 2011 3:39
  9. While histopathology of excised tissue remains the gold standard for diagnosis, several new, non-invasive diagnostic techniques are being developed. They rely on physical and biochemical changes that precede and ...

    Authors: Waseem K Jerjes, Tahwinder Upile, Brian J Wong, Christian S Betz, Henricus J Sterenborg, Max J Witjes, Kristian Berg, Robert van Veen, Merrill A Biel, Adel K El-Naggar, Charles A Mosse, Malini Olivo, Rebecca Richards-Kortum, Dominic J Robinson, Jennifer Rosen, Arjun G Yodh…
    Citation: Head & Neck Oncology 2011 3:38
  10. Intraorbital metastases of breast cancer is rare with only 3-10% of all ocular metastases. We report a case of orbital metastases as first sign of systemic metastatic spread in a female patient with breast can...

    Authors: André M Eckardt, Majeed Rana, Harald Essig and Nils-Claudius Gellrich
    Citation: Head & Neck Oncology 2011 3:37
  11. A case of lipomatous tubular adenoma (LTA) with syringocystadenom papilliferum (SCAP) arising from the external auditory canal in a 25-year-old man is described and to the best of our knowledge through literat...

    Authors: Tzu-Cheng Su, Ko-Hung Shen, Hsin-kai Wang, Pei-Yi Chu and Mei-Ling Chen
    Citation: Head & Neck Oncology 2011 3:36
  12. Hypoxia seems to be an influencing factor for oral squamous cell carcinomas (SCC), and several immunohistochemical markers have been discussed in this regard. The aim of the present study was to evaluate preop...

    Authors: Claudia Cordella, Heinz-Theo Luebbers, Valentina Rivelli, Klaus W Grätz and Astrid L Kruse
    Citation: Head & Neck Oncology 2011 3:35
  13. To report the outcomes of patients with locoregionally advanced and high- risk salivary gland malignancies treated with surgery followed by adjuvant chemoradiotherapy.

    Authors: Aaron W Pederson, Joseph K Salama, Daniel J Haraf, Mary Ellen Witt, Kerstin M Stenson, Louis Portugal, Tanguy Seiwert, Victoria M Villaflor, Ezra EW Cohen, Everett E Vokes and Elizabeth A Blair
    Citation: Head & Neck Oncology 2011 3:31
  14. This study aimed to evaluate acute major toxicities, the response rate, 3-year overall survival and progression-free survival rate of locally advanced nasopharyngeal carcinoma patients on concurrent carboplati...

    Authors: Tanadech Dechaphunkul, Kowit Pruegsanusak, Duangjai Sangthawan and Patrapim Sunpaweravong
    Citation: Head & Neck Oncology 2011 3:30
  15. Various surgical options are available for reconstruction of intraoral soft tissue defects. For smaller defects of the oral mucosa in different anatomic locations of the oral cavity the nasolabial flap is a ve...

    Authors: Andre M Eckardt, Horst Kokemüller, Frank Tavassol and Nils-Claudius Gellrich
    Citation: Head & Neck Oncology 2011 3:28
  16. In this retrospective study, we present a clinical review of our experience with tongue cancer in order to obtain valid criteria for therapeutic decision-making.

    Authors: Horst Kokemueller, Majeed Rana, Jennifer Rublack, Andre Eckardt, Frank Tavassol, Paul Schumann, Daniel Lindhorst, Martin Ruecker and Nils-Claudius Gellrich
    Citation: Head & Neck Oncology 2011 3:27
  17. We report a case of a cervical rheumatoid nodule in close relation to the hyoid bone mimicking a metastatic carcinoma. A 74-year-old female with a 15-year history of rheumatoid arthritis (RA) on treatment with...

    Authors: Fernando Gomez-Rivera, Adel K El-Naggar, Nandita Guha-Thakurta and Michael E Kupferman
    Citation: Head & Neck Oncology 2011 3:26
  18. The antibody-based targeted delivery of bioactive molecules to tumour vasculature is an attractive avenue to concentrate therapeutic agents at cancer sites, while sparing normal organs. L19, F8 and F16 are thr...

    Authors: Kathrin Schwager, Alessandra Villa, Christoph Rösli, Dario Neri, Maria Rösli-Khabas and Gerhard Moser
    Citation: Head & Neck Oncology 2011 3:25
  19. Nutrition is crucial to successful outcomes in peri-operative head and neck cancer patients. Nasogastric feeding tubes are an accepted and safe method of providing enteral nutrition in the short-term. Many met...

    Authors: Tahwinder Upile, Paul Stimpson, Miles Christie, Jaspal Mahil, Hitesh Tailor and Waseem K Jerjes
    Citation: Head & Neck Oncology 2011 3:24
  20. Functional and cosmetic defects in the maxillofacial region are caused by various ailments and these defects are addressed according to their need. Simplicity of procedure, intact facial function and esthetic ...

    Authors: Majeed Rana, Riaz Warraich, Horst Kokemüller, Juliane Lemound, Harald Essig, Frank Tavassol, André Eckardt and Nils-Claudius Gellrich
    Citation: Head & Neck Oncology 2011 3:23
  21. Metastatic mesothelioma to the oral cavity arises from the pleura or peritoneum and distant hematogenous metastases are seen in more than half of cases but only a few cases are reported to the oral cavity.

    Authors: Stephanie Moser, Marc Beer, Georg Damerau, Heinz-Theo Lübbers, Klaus W Grätz and Astrid L Kruse
    Citation: Head & Neck Oncology 2011 3:21
  22. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy in the world in developed countries. Despite the intense research in the area of squamous cell carcinomas of head and neck (HNS...

    Authors: Jenni K Peltonen, Kirsi H Vähäkangas, Henni M Helppi, Risto Bloigu, Paavo Pääkkö and Taina Turpeenniemi-Hujanen
    Citation: Head & Neck Oncology 2011 3:20
  23. This cross-sectional study objects to measure, subjectively and objectively, the voice and life quality of patients with oral cavity, pharyngeal and laryngeal cancer, after organ-preservation treatment.

    Authors: Renata JDS Campos, Cristina TV Maciel, Marcelle G Cesca and Isabel CG Leite
    Citation: Head & Neck Oncology 2011 3:19
  24. Follow-up of patients with oral cancer is being questioned with regard to financial costs and effectiveness. Therefore, the aim of the present study was to evaluate whether local recurrence and cervical lymph ...

    Authors: Valentina Rivelli, Heinz T Luebbers, Franz E Weber, Claudia Cordella, Klaus W Grätz and Astrid L Kruse
    Citation: Head & Neck Oncology 2011 3:18
  25. This study aimed to evaluate clinical, laboratory, ultrasound (US) and scintigraphyc parameters in thyroid nodule and to develop an auxiliary model for clinical application in the diagnosis of malignancy.

    Authors: Frederico FR Maia, Patrícia S Matos, Bradley P Silva, Ana T Pallone, Elizabeth J Pavin, José Vassallo and Denise E Zantut-Wittmann
    Citation: Head & Neck Oncology 2011 3:17
  26. Oncogenous osteomalacia (OOM), which is also known as tumour-induced osteomalacia, is a rare condition associated with a neoplasm and a related systemic bone demineralization caused by renal phosphate wasting....

    Authors: Pavel Komínek, Ivo Stárek, Marie Geierová, Petr Matoušek and Karol Zeleník
    Citation: Head & Neck Oncology 2011 3:16
  27. Fibrous dysplasia (FD) and aneurysmal bone cyst (ABC) are uncommon benign intraosseous lesions. Simultaneous occurrence of both lesions is extremely rare. We present an example of concomitant FD and ABC in a 7...

    Authors: Abdullah Sulieman Terkawi, Khalid H Al-Qahtani, Eman Baksh, Lahbib Soualmi, Asim El-Bagir Mohamed and Abdulrahman J Sabbagh
    Citation: Head & Neck Oncology 2011 3:15
  28. The pectoralis major myocutaneous flap (PMMF) is a commonly used flap in reconstructive head and neck surgery, but in literature, the flap is also associated with a high incidence of complications in addition ...

    Authors: Astrid L Kruse, Heinz T Luebbers, Joachim A Obwegeser, Marius Bredell and Klaus W Grätz
    Citation: Head & Neck Oncology 2011 3:12
  29. We examine the potential prognostic and predictive roles of EGFR variant III mutation, EGFR gene copy number (GCN), human papillomavirus (HPV) infection, c-MET and p16 INK4A

    Authors: Nicole G Chau, Bayardo Perez-Ordonez, Katherine Zhang, Nhu-An Pham, James Ho, Tong Zhang, Olga Ludkovski, Lisa Wang, Eric X Chen, Ming-Sound Tsao, Suzanne Kamel-Reid and Lillian L Siu
    Citation: Head & Neck Oncology 2011 3:11
  30. Oral squamous cell carcinoma (OSCC) is characterized by an aggressive growth pattern, local invasiveness, and spread to cervical lymph nodes. Overall survival rates have not improved, primarily due to locoregi...

    Authors: Frank Tavassol, Oliver F Starke, Horst Kokemüller, Gerd Wegener, Corinna CM Müller-Tavassol, Nils-Claudius Gellrich and André Eckardt
    Citation: Head & Neck Oncology 2011 3:10
  31. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide with a poor prognosis. Human papilloma virus (HPV) infection is associated with 20% HNSCC, and 50% of oropharyngeal c...

    Authors: Matthew Harris, Xing Guo Wang, Zewei Jiang, Gary L Goldberg, Arturo Casadevall and Ekaterina Dadachova
    Citation: Head & Neck Oncology 2011 3:9
  32. The complete surgical removal of disease is a desirable outcome particularly in oncology. Unfortunately much disease is microscopic and difficult to detect causing a liability to recurrence and worsened overal...

    Authors: Tahwinder Upile, Waseem K Jerjes, Henricus J Sterenborg, Brian J Wong, Adel K El-Naggar, Justus F Ilgner, Ann Sandison, Max J Witjes, Merrill A Biel, Robert van Veen, Zaid Hamdoon, Ann Gillenwater, Charles A Mosse, Dominic J Robinson, Christian S Betz, Herbert Stepp…
    Citation: Head & Neck Oncology 2011 3:7
  33. The incidence of tonsil cancers has increased in several countries. French data on HPV prevalence in tonsil cancers are scarce. The objective of this study was thus to assess the overall and type specific HPV ...

    Authors: Jean Lacau St Guily, Christine Clavel, Claire Okaïs, Jean-Luc Prétet, Agnès Beby-Defaux, Gérard Agius, Philippe Birembaut, Anne-Carole Jacquard, Yann Léocmach, Benoît Soubeyrand, Didier Riethmuller, François Denis and Christiane Mougin
    Citation: Head & Neck Oncology 2011 3:6
  34. Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous neoplasm associated with a high cure rate. We present a case of aggressive DFSP with fibrosarcomatous areas in the head and neck. A 28-year-old Medite...

    Authors: Nikolaos Angouridakis, Panagiotis Kafas, Waseem Jerjes, Stefanos Triaridis, Tahwinder Upile, Georgios Karkavelas and Angelos Nikolaou
    Citation: Head & Neck Oncology 2011 3:5
  35. Squamous cell carcinoma (SCC) of the tonsil is the most common malignant tumour of the oropharynx. Paediatric tonsillectomy is one of the most commonly performed procedures in Otorhinolaryngology. SCC of the t...

    Authors: Christopher J Skilbeck, Jean-Pierre Jeannon, Mary O'Connell, Peter R Morgan and Ricard Simo
    Citation: Head & Neck Oncology 2011 3:4
  36. Population ageing is increasing the number of people annually diagnosed with cancer worldwide, once most types of tumours are age-dependent. High-quality healthcare in geriatric oncology requires a multimodal ...

    Authors: Augusta P Silveira, Joaquim Gonçalves, Teresa Sequeira, Cláudia Ribeiro, Carlos Lopes, Eurico Monteiro and Francisco L Pimentel
    Citation: Head & Neck Oncology 2011 3:3
  37. Oral squamous cell carcinoma has a remarkable incidence worldwide and a fairly onerous prognosis, encouraging further research on factors that might modify disease outcome.

    Authors: Anna G Zygogianni, George Kyrgias, Petros Karakitsos, Amanta Psyrri, John Kouvaris, Nikolaos Kelekis and Vassilis Kouloulias
    Citation: Head & Neck Oncology 2011 3:2
  38. The expression non Hodgkin lymphoma is used to cover a wide group of lymphoid neoplasias unrelated to Hodgkin's disease, due to the huge histological variety and the tendency to affect organs and tissues that ...

    Authors: Francesco Inchingolo, Marco Tatullo, Fabio M Abenavoli, Massimo Marrelli, Alessio D Inchingolo, Angelo M Inchingolo and Gianna Dipalma
    Citation: Head & Neck Oncology 2011 3:1
  39. Although TP53 mutations in human tumours generally have been extensively studied, the significance of p53 in the aetiology of head and neck cancers is still incompletely characterized. In recent years, considerab...

    Authors: Jenni K Peltonen, Henni M Helppi, Paavo Pääkkö, Taina Turpeenniemi-Hujanen and Kirsi H Vähäkangas
    Citation: Head & Neck Oncology 2010 2:36
  40. The overall objective of this study was to develop a nanoparticle formulation for dual modality imaging of head and neck cancer. Here, we report the synthesis and characterization of polymeric phospholipid-bas...

    Authors: Rajiv Kumar, Tymish Y Ohulchanskyy, Steve G Turowski, Mark E Thompson, Mukund Seshadri and Paras N Prasad
    Citation: Head & Neck Oncology 2010 2:35
  41. Chemoradiotherapy for head and neck cancer (SCCHN) is challenging in elderly, multi-morbid patients. Radioimmunotherapy (RIT) with cetuximab provides an option to enhance efficacy of radiotherapy without incre...

    Authors: Alexandra D Jensen, Zazie P Bergmann, Helena Garcia-Huttenlocher, Kolja Freier, Jürgen Debus and Marc W Münter
    Citation: Head & Neck Oncology 2010 2:34