Pre-operative planning for mandibular reconstruction - A full digital planning workflow resulting in a patient specific reconstruction
- Harald Essig†1,
- Majeed Rana†1Email author,
- Horst Kokemueller1,
- Constantin von See1,
- Martin Ruecker1,
- Frank Tavassol1 and
- Nils-Claudius Gellrich1
© Essig et al; licensee BioMed Central Ltd. 2011
Received: 26 September 2011
Accepted: 3 October 2011
Published: 3 October 2011
Reconstruction of large mandiblular defects following ablative oncologic surgery could be done by using vascularized bone transfer or, more often, primarily with simultaneous or delayed bone grafting, using load bearing reconstruction plates. Bending of these reconstruction plates is typically directed along the outer contour of the original mandible. Simultaneously or in a second operation vascularized or non-vascularized bone is fixed to the reconstruction plate. However, the prosthodontic-driven backward planning to ease bony reconstruction of the mandible in terms of dental rehabilitation using implant-retained overdentures might be an eligible solution. The purpose of this work was to develop, establish and clinically evaluate a novel 3D planning procedure for mandibular reconstruction.
Materials and methods
Three patients with tumors involving the mandible, which included squamous cell carcinoma in the floor of the mouth and keratocystic odontogenic tumor, were treated surgically by hemimandibulectomy.
In primary alloplastic mandible reconstruction, shape and size of the reconstruction plate could be predefined and prebent prior to surgery.
This study provides modern treatment strategies for mandibular reconstruction.
KeywordsMandibular reconstruction backward planning patient specific implant computer-assisted surgery
Indications for partial and total mandibulectomy include malignancies especially squamous cell carcinomas (SCC), benign tumors such as ameloblastomas and sequelae of radiotherapy such as osteoradionecrosis. Defect size in ablative surgery mainly depends on dignity and dimensions of the pathology. Following mandibulectomy, reconstruction of the mandible is mainly done with vascularized bone grafts or alloplastic materials (reconstruction plates). However, irrespective of the type of primary hard tissue reconstruction is simultaneous adequacy of the soft tissue reconstruction equally important: only a well vascularized soft tissue envelope allows for a successful hard tissue reconstruction. Even large series of mandibular reconstruction after ablative surgery or major trauma in literature show that oral rehabilitation of patients with large segmental defects is still a challenge [1–4]. Besides soft tissue inadequacies due to ablative procedures and scarring, the method of bony reconstruction plays an important role on the functional and aesthetic result [2, 5–8]. Preferred donor sites for vascularized bone with good survival rates are the fibula, iliac bone and scapula [9–11]. Limitations in terms of either primary or secondary dental implant-based rehabilitations are especially the lack of recreating the alveolar height and following adverse crown-implant ratio. But also the lateral and sagittal extension of the bone volume determines the success rate of dental implants and therefore is crucial for oral rehabilitation in cancer patients . Some authors prefer secondary mandibular reconstructions with free bone grafts which provide adequate volume to insert implants [12–14]. A prerequisite to apply this method is a secure vascularized soft tissue bed.
Pre-operative planning is highly-developed [15–17] and image-guided surgery well-established. An ongoing issue in planning procedures is that virtual reconstruction is based on a true-to-original outer contour reconstruction . However, dimension limitations of bone grafts, especially in height and width, do not match with prosthodontic needs and often result in unavoidable malpositioned dental implants with sequentially lateral cross-bite situation. Furthermore, dysbalance in soft-tissue-to-bone-to-implant relationship result in later periimplantatis with consecutive early to late implant loss. Aim of this study is to implicate the ideal, i.e. prosthodontic driven planning and positioning of bone grafts in the planning procedure respecting the desired implant position: backward planning independent of the reconstructive technique. This requires patient specific pre-bending of the reconstruction plate to guide the bone graft into the desired position. So the outer contour of the mandible is not anymore the basis for bending the plate.
Materials and methods
Patient's preoperative demographic data
Keratocystic odontogenic tumor
Mirroring of the unaffected site, STL-modell, prebending
Autosegmentation, STL-modell, prebending
Backward-Planning using Autosegmentation, SmartShaper, virtual Implant positioning
Virtual Planning Technique
The imaging and planning platform used in this study was iPlan 3.0 (Brainlab®, Feldkirchen, Germany). This platform allows for alignment of the DICOM data set, viewing and analysis and provides 3D tools for the planning procedure such as mirroring tools, autosegmentation with atlas-function and a three-dimensional modification tool named SmartShaper. iPlan enables import of different imaging modalities and allows to automatically image-fuse these data. That facilitates not only the pre-operative analysis of the data but also the post-operative quality control. Furthermore this platform allows for intra-operative navigation of the virtual plan which is important for midface and skullbase procedures, however, this was not used in the presented cases.
The basic data used for the virtual planning included the pre-operative computed tomography (CT) imaging data with a maximum slice thickness of 1 mm. The data were transferred on the computer and reconstructed into 3D images. Different planning modalities include mirroring tools (case 1), autosegmentation tools (case 2) and the backward planning tool (case 3). The backward planning is mainly based on size-variable ideal dental arch models with adjustable and truly designable virtual hollow cylinders. These hollow cylinders define not only the implant position but also the needed peri-implant bone volume. Thus desired bone position as a required subvolume within the later bone grafts for later insertion of dental implants could be visualized and already considered during the primary alloplastic reconstruction of the mandible.
Outcome of the virtual planning is in each case a virtual template of the mandible (STL-file format) for production of a corporeal stereolithographic model. After prototyping of the model (Phacon GmbH, Leipzig, Germany) a conventional 2.4 Compact UniLOCK reconstruction plate (Synthes®, Umkirch, Germany) was bent to bridge the prospective mandible defect.
After ablative surgery was performed, the preformed reconstruction plate was used for the osteosynthesis. At the time of secondary reconstruction with free iliac bone graft the individual reconstruction plate gives the surgeon a clear direction where the bone should be ideally placed.
The following case studies demonstrate the planning possibilities, firstly starting with an unilateral defect using mirroring tools and patient specific reconstruction plate (case 1), secondly using the autosegmentation to virtual reconstruct the mandible (case 2) and finally presenting the prosthodontic driven "backward planning" for optimized bone graft position (case 3).
Patient underwent en bloc tumor resection with partial mandibulectomy and bilateral neck dissection. The individual prebent reconstruction plate was inserted. The operation went without complications and secondary reconstruction is planned. Plate profile created good visual appearance of the lower third of the face. Besides of possible intraoral soft tissue deficiencies, large bone grafts which offer especially large dimension in width and height would be needed to enable adequate oral implantation and to prevent ending up in a cross-bite situation.
The patient was a 66-year-old female who complained of dysphagia and pain caused by a tumor located on the alveolar ridge with infiltration of the anterior floor of the mouth and tongue. Diagnosis of squamous cell carcinoma was confirmed by preoperative biopsy (pT4 - Stage 4 UICC).
In primary alloplastic mandible reconstruction, shape and size of the reconstruction plate could be predefined and prebent prior to surgery. This could improve accuracy of the contour of the plate. In limited mandible defects, good results could be achieved with this simple planning method (case 1). In larger defects (case 2) simple mirroring tools are not feasible. The recent iPlan-Software allows by using the autosegmentation mode a virtual reconstruction of the mandible and following prebending of plates.
The base of planning is up to now mostly the outer contour of the mandible. But in large reconstructions, this leads to an inappropriate positioning of bone grafts in secondary reconstruction due to the limited dimensions of bone grafts. In case 3 we could demonstrate the significant discrepancy between original mandible contour and desired neomandible contour regarding later oral rehabilitation.
Adequate reconstruction should offer replacement of dentition and provide improved deglutition, mastication, and speech  and therefore significantly contributes to oral rehabilitation. These clinically relevant parameters depend mainly on soft tissue lining, on the mobility of the tongue and on the amount of bone available for dental implantation.
Soft tissue lining has to be addressed at least twice: in mandibular reconstruction to allow a sufficient blood supply for the transplanted bone with its bradytrophic character and before or after implant insertion to allow a non-irritant interface between mucosa and implant. It is reported that in accompanying soft tissue deficiencies mandibular reconstruction is preferably treated with vascularized bone grafts. Buchbinder et al. demonstrate that osseocutaneous flaps offer the most rapid rehabilitation . In contrast, there is evidence for a better outcome in oral rehabilitation of non-vascularized iliac crest grafts compared to osseocutaneous flaps .
Problems of bony reconstruction include undercorrection of the lower facial contour, unsatisfying midline match and unfavourable sagittal maxillary-mandibular relationship  due to limited bone graft volume. In literature, however, bony deficiency in width and height as an important factor for oral rehabilitation is rarely mentioned  and even publications which focus on virtual planning in large mandible reconstruction do not provide post-operative three-dimensional imaging  to make advantage of virtual planning comprehensible. Implant insertion should meet a sufficent bony base for rehabilitation .
There are many reports about virtual planning of mandible reconstruction. Virtual planning appears to have positive impact on the reconstruction of major mandibular defects . There are commercially available planning platforms which offer planning support via web sessions  and also multiple research-and-development tools that allow for example as well for rapid prototyping [17, 20]. The recent iPlan-Software (Brainlab AG, Feldkirchen, Germany) is a highly sophisticated commercially available product which eases planning procedures by autosegmentation and three-dimensional manipulation tools. Export function for STL-files enables rapid prototyping and intra-operative image guidance allows for computer-assisted surgery. Post-operative quality control is automatically done by superimposing pre-operative data sets including the 3D-planning with the post-operative scan.
The recent software version iPlan 3.0 allows for the described workflow in backward-planning of an ideal neomandible. A substantial limitation in commercially available planning platforms, at the moment, is the lack of an automated collision detection to find an ideal occlusal position with maximum intercuspidation. In edentulous mandible this is of subordinate importance and simplification by virtually rotation the mandible in the desired position seems to be admissible. Further software releases should address these limitations.
Bending of reconstruction plates using 3-dimensional stereolithographic models is reported. These stereolithographic models are based on virtual templates which were standardized exported in STL-file format and produced by specialized companies [15, 21]. The so bended reconstruction plates offer reliable accuracy [22, 23] and could ease as manually bended or as patient-specific implants not only alloplastic mandible reconstruction but also could improve placement of bone grafts to achieve an adequate bony base for later dental implantation. The backward-planning workflow could help to improve oral rehabilitation. There are still reasons for remaining without dental rehabilitation.
This study provides modern treatment strategies for mandibular reconstruction.
Conflict of interest statement
The authors declare that they have no competing interests.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The article processing charges are funded by the Deutsche Forschungsgemeinschaft (DFG), "Open Acess Publizieren".
- Mooren RE, et al: Reconstruction of the mandible using preshaped 2.3-mm titanium plates, autogenous cortical bone plates, particulate cancellous bone, and platelet-rich plasma: a retrospective analysis of 20 patients. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 2010, 68 (10): 2459-67. 10.1016/j.joms.2009.12.006.View ArticleGoogle Scholar
- Bak M, et al: Contemporary reconstruction of the mandible. Oral oncology. 2010, 46 (2): 71-6. 10.1016/j.oraloncology.2009.11.006.View ArticlePubMedGoogle Scholar
- Kovacs AF: Clinical analysis of implant losses in oral tumor and defect patients. Clinical oral implants research. 2000, 11 (5): 494-504. 10.1034/j.1600-0501.2000.011005494.x.View ArticlePubMedGoogle Scholar
- Schoen PJ, et al: Prosthodontic rehabilitation of oral function in head-neck cancer patients with dental implants placed simultaneously during ablative tumour surgery: an assessment of treatment outcomes and quality of life. International journal of oral and maxillofacial surgery. 2008, 37 (1): 8-16. 10.1016/j.ijom.2007.07.015.View ArticlePubMedGoogle Scholar
- Miles BA, et al: Mandible reconstruction. Current opinion in otolaryngology & head and neck surgery. 2010, 18 (4): 317-22. 10.1097/MOO.0b013e32833aaf7e.View ArticleGoogle Scholar
- Yilmaz M, et al: A comparison of vascularized fibular flap and iliac crest flap for mandibular reconstruction. The Journal of craniofacial surgery. 2008, 19 (1): 227-34.PubMedGoogle Scholar
- Iizuka T, et al: Oral rehabilitation after mandibular reconstruction using an osteocutaneous fibula free flap with endosseous implants. Factors affecting the functional outcome in patients with oral cancer. Clinical oral implants research. 2005, 16 (1): 69-79.View ArticlePubMedGoogle Scholar
- Schusterman MA, et al: Use of the AO plate for immediate mandibular reconstruction in cancer patients. Plastic and reconstructive surgery. 1991, 88 (4): 588-93. 10.1097/00006534-199110000-00005.View ArticlePubMedGoogle Scholar
- Hidalgo DA: Fibula free flap: a new method of mandible reconstruction. Plastic and reconstructive surgery. 1989, 84 (1): 71-9. 10.1097/00006534-198907000-00014.View ArticlePubMedGoogle Scholar
- Urken ML, et al: Oromandibular reconstruction using microvascular composite flaps: report of 210 cases. Archives of otolaryngology--head & neck surgery. 1998, 124 (1): 46-55.View ArticleGoogle Scholar
- Sullivan MJ, et al: Free scapular osteocutaneous flap for mandibular reconstruction. Archives of otolaryngology--head & neck surgery. 1989, 115 (11): 1334-40.View ArticleGoogle Scholar
- Schliephake H, et al: Comparison of the late results of mandibular reconstruction using nonvascularized or vascularized grafts and dental implants. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 1999, 57 (8): 944-50. 10.1016/S0278-2391(99)90015-0. discussion 950-1View ArticleGoogle Scholar
- Foster RD, et al: Vascularized bone flaps versus nonvascularized bone grafts for mandibular reconstruction: an outcome analysis of primary bony union and endosseous implant success. Head & neck. 1999, 21 (1): 66-71. 10.1002/(SICI)1097-0347(199901)21:1<66::AID-HED9>3.0.CO;2-Z.View ArticleGoogle Scholar
- Goh BT, et al: Mandibular reconstruction in adults: a review. International journal of oral and maxillofacial surgery. 2008, 37 (7): 597-605. 10.1016/j.ijom.2008.03.002.View ArticlePubMedGoogle Scholar
- Cohen A, et al: Mandibular reconstruction using stereolithographic 3-dimensional printing modeling technology. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2009, 108 (5): 661-6. 10.1016/j.tripleo.2009.05.023.View ArticlePubMedGoogle Scholar
- Eckardt A, Swennen GR: Virtual planning of composite mandibular reconstruction with free fibula bone graft. The Journal of craniofacial surgery. 2005, 16 (6): 1137-40. 10.1097/01.scs.0000186306.32042.96.View ArticlePubMedGoogle Scholar
- Juergens P, et al: Computer simulation and rapid prototyping for the reconstruction of the mandible. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 2009, 67 (10): 2167-70. 10.1016/j.joms.2009.04.104.View ArticleGoogle Scholar
- Roser SM, et al: The accuracy of virtual surgical planning in free fibula mandibular reconstruction: comparison of planned and final results. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 2010, 68 (11): 2824-32. 10.1016/j.joms.2010.06.177.View ArticleGoogle Scholar
- Buchbinder D, et al: Functional mandibular reconstruction of patients with oral cancer. Oral surgery, oral medicine, and oral pathology. 1989, 68 (4 Pt 2): 499-503. discussion 503-4View ArticlePubMedGoogle Scholar
- Krol Z, et al: Surgery planning tools for the osseous grafting treatment. Biomedizinische Technik. Biomedical engineering. 2002, 47 (Suppl 1 Pt 1): p. 97-100.View ArticleGoogle Scholar
- Derand P, Hirsch JM: Virtual bending of mandibular reconstruction plates using a computer-aided design. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 2009, 67 (8): 1640-3. 10.1016/j.joms.2009.03.039.View ArticleGoogle Scholar
- Klug C, et al: Point-to-point computer-assisted navigation for precise transfer of planned zygoma osteotomies from the stereolithographic model into reality. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 2006, 64 (3): 550-9. 10.1016/j.joms.2005.11.024.View ArticleGoogle Scholar
- Schicho K, et al: Accuracy of treatment planning based on stereolithography in computer assisted surgery. Medical physics. 2006, 33 (9): 3408-17. 10.1118/1.2242014.View ArticlePubMedGoogle Scholar
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