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FDG-PET staging and importance of lymph node SUV in head and neck cancer



The role of positron emission tomography (PET) with fluoro-deoxy-glucose (FDG) in the staging of head and neck cancer (HNC) is unclear. The NCCN guidelines do not recommend FDG-PET as a part of standard workup. The purpose of this report is to examine the role of FDG-PET imaging in altering management and providing prognostic information for HNC.


Retrospective review of HNC patients who had a staging FDG-PET scan performed at either Thomas Jefferson University or University of Kansas Medical Center between the years 2001 and 2007. A total of 212 PET scans were performed in patients who went on to receive radiotherapy.


The median follow-up time for all patients was 469 days. The PPV and NPV of PET imaging to correctly identify lymph node status was 94% and 89% respectively. Lymph nodes with extracapsular extension (ECE) had higher SUVs than nodes without ECE, 11.0 vs. 5.0 (p < 0.0007). Maximum SUV for the primary tumor > 8.0 was predictive of worse overall survival (p < 0.045), while the SUV of the lymph nodes was predictive for distant recurrence at one year--with a mean SUV value of 10.4 for patients with distant failure vs. 7.0 without (p < 0.05).


FDG-PET staging in head and neck cancer has good positive and negative predictive values in determining lymph node status. The maximum SUV of the primary tumor is predictive of overall survival. This is the first report to find that the SUV of a lymph node is predictive for ECE and also for distant recurrence.


Approximately 47,500 new cases of head and neck cancer (HNC) are diagnosed annually in the United States [1], the cure rates for HNC, especially in advanced disease, remains poor [2]. Because of this there have been efforts to improve outcomes through the use of targeted agents [3], new radiation techniques such as intensity modulated radiation therapy (IMRT) and image guided radiation therapy (IGRT), as well as new types of diagnostic imaging. Scanning utilizing FDG has become standard of care for many malignant neoplasms [4] for its ability to more accurately stage tumors, and thus alter therapeutic decision making, compared to conventional imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI).

The use of FDG-PET scanning in head and neck cancer is more controversial. NCCN guidelines do not include PET scans as part of routine staging, and many institutions use MRI or ultrasound guided biopsies rather than PET scans. The Radiation Therapy Oncology Group (RTOG) utilizes the clinical exam, chest x-ray, and pre-treatment CT scan as their standard workup.

Despite the lack of acceptance of staging PET scans into guidelines and cooperative groups, there are a number of studies that have examined the role of PET scans in HNC staging. Several studies [58] have looked at the value of PET in initial staging and the finding of metastatic disease or secondary cancers; the incidence seen in some of the larger studies [7, 8] is 11.1 to 12.9%. The staging of lymph node status with PET has also been examined [5, 917]; the sensitivity of PET in this regard ranges from 47 to 100% while the specificity ranges from 87 to 100%.

The prognostic value of SUVs is another unresolved issue with PET scanning. In theory, a greater SUV would correspond with a more aggressive tumor. While some authors [1824] have found a relationship between maximum tumor SUV and clinical outcome, others [25, 26] have not found this to be true. A few reports have examined the role of nodal SUV and outcome [18, 19, 27], with inconclusive results. Having prognostic information, especially in terms of patterns of failure, would be very useful. If there was a way to determine which patients had a greater risk of distant failure versus local failure, clinicians would be able to determine who would be ideal candidates for induction chemotherapy.

One of difficulties in interpreting the large number of studies on the topic of PET scans in the staging of HNC is the low number of patients in any one study. To increase the patient numbers we have combined the databases of two institutions with high-volume HNC services. This allows for better assessment of the capabilities of PET scans for staging HNC.


This is a retrospective review of PET scans used in staging at two academic institutions; Thomas Jefferson University Hospital (Philadelphia, PA) and the Kansas University Medical Center (Kansas City, KS). Prior to beginning the review, approval was granted from the institutional review board (IRB) of each institution. Using the PET scan registry of both institutions, all of the PET scans for HNC that had been performed from 2000 to 2007 were analyzed. Patients who went on to have adjuvant or definitive radiotherapy with or without chemotherapy were included in the final analysis.

Images were acquired with either a PET or PET coupled with a low energy CT utilized for attenuation correction (CTAC) of the PET data. PET scans performed at Thomas Jefferson University Hospital used a Siemens Biograph 6 (Siemens Medical Solutions USA, Inc, Malvern, PA). For the PET/CTAC images, the CT component was a GE Lightspeed, 16 slice scanner (General Electric, Milwaukee, WI). Kansas University Medical Center used a Siemens ECAT ART (Advanced Rotational Tomograph) and a GE Discovery ST 16 slice scanner. Imaging protocols were similar at both institutions. Before the PET scan, all patients were required to fast for four hours, and blood glucose had to be less than 180 mg/dl. Ten to 15 mCurie (370-555 MBq) of (18F)-FDG was injected and 45 to 60 minutes was allowed for uptake before patient imaging. Patients were instructed to minimize any talking, chewing, swallowing, or movement of the head.

For fused PET/CT images, the CTAC and PET images were hardware coregistered in a single session. Non-contrast-enhanced CT imaging for attenuation correction and anatomic correlation was performed first from the vertex of the skull to below the kidneys. First the CT scan was completed using 180-mA tube current, 140-kV tube voltage, 0.5-second tube rotation, helical pitch of 1:1, and reconstructed slice thickness of 4.25 mm. The CT portion was acquired in less than 30 seconds. Immediately after the CT scan, a PET scan was acquired starting at the skull vertex with an acquisition time of 5 minutes per bed position with a one-slice overlap at the borders of the 14.6-cm field of view. Data were reconstructed using OSEM iterative reconstruction with two iterations and 28 subsets. Post-processing with a post filter at 5.45 mm full width at half maximum (FWHM), and a loop filter at 3.91 mm FWHM on a 128 × 128 matrix was then carried out. Images were viewed on a Xeleris (GE medical Systems) workstation. For scans that did not have CT fusion, the PET scan data was read in conjunction with other radiology exams (for example CT scan or MRI) if available.

Interpretation of the images consisted of reviewing the nuclear medicine report, information was gathered concerning areas of increased uptake and, if available, the maximum SUV. Radiology review was performed independently of reviewing the clinical chart. Clinical information was obtained from a retrospective chart review. Analysis was performed after all of the pertinent clinical and radiographic information had been gathered. Statistical analysis was performed using Graphpad (GraphPad Software Inc. La Jolla, CA) software.


A total of 212 patients (212 PET scans) were analyzed in this study, patient characteristics are outlined in Table 1. The majority of patients had advanced HNC, 80.2% were either stage III or IV. The median follow-up for all patients was 469 days with a range of 40 to 1596 days as measured from the end of radiation.

Table 1 Patient Characteristics

SUVs were available for 152 of the masses and 79 of the lymph nodes, 52 patients did not have a reported SUV (results for these patients were reported as positive or negative). The median maximum SUV was 8.75 with a range of 1 to 41 for the main tumor mass. The median maximum SUV was 5.95 with a range of 2 to 25 for the lymph node, when multiple lymph nodes were found, only the lymph node with the highest SUV was used.

At last follow-up, 119 patients were still alive; Kaplan-Meier median overall survival for the entire cohort was 886 days, Kaplan-Meier median disease free survival for entire cohort was 726 days. When SUV of the tumor mass was analyzed in terms of overall survival using log-rank (Mantel-Cox) test, it was found that SUV > 8 was statistically significant for a worse overall survival (p < 0.045) with an overall survival of 669 days for patients with an SUV of the mass greater than 8 and a median overall survival of 984 days for patients with a SUV of the mass less than 8. Figure 1.

Figure 1
figure 1

Kaplan Meier Overall Survival. Figure 1 shows overall survival by mass SUV greater and lesser than 8. Curves are significantly different (p < 0.045).

Seventy-eight patients had a recurrence, 35 distant and 43 local, with a median time to recurrence of 135 days. One hundred and thirty one (61.7%) had local control with no evidence of disease at last follow-up or at time of death from non-cancer causes. Twenty patients had persistent disease after radiation, 5 of these patients had distant recurrence as well. There was a trend for patients with an SUV of the mass ≤8 to have improved local control, but this did not reach statistical significance (p = 0.16) Figure 2. The maximum lymph node SUV was found to be predictive for distant failure (p < 0.0001), but not for overall or local failure. Median lymph node SUV was 10.0 for patients with distant failure vs. 5.2 without. Figure 3.

Figure 2
figure 2

Kaplan Meier Disease Free Survival. Figure 2 represents disease free survival by mass SUV greater and lesser than 8. The curves are not statistically significantly different (p = 0.16).

Figure 3
figure 3

Kaplan Meier Time to Distant Recurrence. This graph shows time to distant recurrence with nodal SUV greater to and lesser than 10. The curves are statistically significantly different (p < 0.011).

One hundred and ten patients had a neck dissection performed after the PET scan prior to radiotherapy. PET scan in these patients was obtained a median of 12 days prior to the surgical neck dissection (range 3 to 91 days). For these 110 patients, the radiographic lymph node status was compared to the final surgical pathology. Four false positives and 5 false negatives were found giving a sensitivity of 92.5%, specificity of 90.7%, positive predictive value (PPV) of 93.9% and a negative predictive value (NPV) of 88.6%. Of the 5 false negative PET scans, there was 1 T1 base of tongue cancer, 1 T2 parotid, 1 T2 oral tongue, and 2 T4 oral cavity. All patients with a false negative PET scan had one lymph node positive for metastatic disease found on subsequent neck dissection. For the false positive results, there was 1 T2 oral tongue, 1 T4 oral cavity, 1 T4 larynx, and 1 T2 tonsil. Neck dissections for the 4 false positive PET scans showed no positive lymph nodes with a median of 23 (range 9 to 27) nodes dissected.

Twenty-two patients had ECE of a lymph node found on neck dissection; fifteen of these patients had reported SUV of the lymph node. The median SUV of these lymph nodes was 11.9 versus 5.0 for lymph nodes without ECE, which was significantly different (p < 0.0007) on a student's T-test. ECE was found in 6 patients with N1 nodal disease and 16 patients with N2-3 nodal disease. On a repeated measures ANOVA, there was no difference in median SUV of the lymph node based on nodal status (N1 versus N2-3).

Imaging modality was a PET scan in 119 patients and a PET/CT scan in 93 patients. For the 110 patients with post-PET neck dissections, 55 had PET-CT scans and 55 had PET scans. When analyzed for any differences between the imaging modalities by nodal staging, PET/CT scans had 2 false positive results and 0 false negatives while PET without CT fusion had 2 false positives and 5 false negatives. The sensitivity for the PET/CT was 100% with a specificity of 90.1% and a PPV of 94% and NPV of 100%. For PET alone, the sensitivity was 85.7%, specificity 90%, PPV of 93.4% and NPV of 78.2%. Using a student's T-test, PET and PET/CT were not statistically significantly different in overall ability to determine lymph node status (p = 0.089).


Several recent innovations have been introduced in efforts to improve the clinical outcome in the treatment of HNC. New radiotherapy technologies such as IMRT and IGRT have improved radiotherapy delivery and new surgical techniques including sentinel lymph node biopsy also have potential for improving HNC therapy. In addition, increased implementation of diagnostic exams such as PET and PET/CT scans have the potential to improve treatment outcomes by providing improved lymph node staging, prognostic, and perhaps predictive factors.

We found excellent positive and negative predictive value for PET scans in determining lymph node status. This finding is in line with several other reports [5, 917]. Table 2. These findings have potential clinical implication in that it may be possible to use staging PET scan results in stratifying patients who should go on to receive neck dissections. Ng et al. [11] found false negative PET scan results depended on the T stage of the tumor with false negative PET scans in 6.7, 10.8, 13.3, and 25% for T1-4 tumors respectively. Our results also demonstrate the low false negative rate in staging PET scans, although we did not find a relation between T stage and false negative rates, likely secondary to the low number of false negative PET scans. A recent meta-anaylsis [28] examining the results of PET scan in cervical lymph node staging found lower sensitivity (79%) and specificity (86%) results than our study. Some explanations for this include the fact that most of the studies in the meta-analysis were older and used PET scan alone rather than combined PET/CT.

Table 2 Results for Staging with PET

Several authors have examined if PET/CT is superior to PET alone in nodal staging [2931]. Bransetter et al. [30] reported that PET/CT was superior to PET alone in HNC lesions, and Schoder et al. [32] arrived at the same conclusion. The overall accuracy in determining lymph node status was not statistically significantly better for PET/CT in this study, but there was a trend towards significance. Although PET/CT had several false-positive results there were no false negatives. The added accuracy of CT fusion with the PET scan, especially in terms of reducing the number of false negative scans, is important in the use of PET/CT to limit surgical neck dissection.

This report and others can help determine the best use for PET scans in the nodal staging of HNC. Our report lends strength to the previously published studies regarding the excellent predictive value of PET scans in determining lymph node status. Having adequate knowledge of lymph node status without the aid of surgical dissection has several potential areas of clinical benefit. Neck dissections add significant morbidity in HNC patients [33] and PET scans may be able to determine which patients do not require a full dissection. If further evidence, perhaps in the form of a prospective trial, can confirm the accuracy of PET scans in lymph node staging, it would be possible to use imaging in lieu of surgery for determining lymph node status.

The role of maximum SUV as a prognostic factor is controversial. Several reports have found a particular SUV value associated with a worse outcome [1824]. However, other authors did not report this association [26, 27]. One factor in the mixed findings of maximum SUV and outcome may be related to the relatively small number of patients in many of these studies. Our data found that SUV of the tumor mass > 8 was associated with worse overall survival. Interestingly, we did not find an association between tumor mass SUV and local control, likely secondary to several late relapses. Fewer reports have focused on the prognostic information of nodal SUV. Schwartz et al. [19] did not find any association between nodal SUV and outcome in 36 patients, Brun et al [20] also failed to find any association and also had 36 patients. Liao et al. [27] examined only oral cavity patients with positive lymph nodes and found that a lymph node SUV of 5.4 predicted for worse outcomes. We found an association between maximum SUV of the lymph node and outcome with nodal SUV > 10 more likely to have distant failure in 79 patients with nodal SUV. One explanation of the discrepancy between our data and that of Schwartz et al. and Brun et al. could be the larger number of patients which would give our study power to detect a true finding.

Although prognostic information, such as tumor mass SUV, is useful, it is not used for management changes. However, the association between maximum lymph node SUV and distant failure has possible clinical implications. One of the current trends (although still unproven) in HNC is neoadjuvant chemotherapy with TPF [34, 35]. If further reports confirm the finding that maximum lymph node SUV > 10 has a higher likelihood of distant failure but not a higher likelihood of local failure, this would be a possible stratification factor for which patients should receive neoadjuvant TPF rather than concurrent therapy.

We also found that maximum SUV was predictive of ECE. ECE is an established risk factor and is one of the indications (the other being positive margins) in determining which patients post-operatively benefit from combined chemoradiotherapy rather than radiotherapy alone [36]. For patients receiving definitive radiotherapy, it may make be beneficial to treat higher SUV lymph nodes (which are more likely to harbor ECE) to a higher dose.

The results of this study need to be interpreted with caution; it is retrospective in nature and includes a variety of head and neck cancer subtypes. In this regard, our study has the same flaws as the majority of other reports examining the utility of FDG-PET in the staging of head and neck cancer. However, this study does have some improved clinical utility secondary to its size (212 PET scans analyzed) and the multi-institution nature of this report. We acknowledge that most of the information gathered are hypotheses generating and that further studies, perhaps in a prospective randomized fashion, will be required to truly determine the utility for PET scans in HNC. Until such studies are completed, large retrospective such as this are needed to provide the best information at this time possible.


FDG-PET scanning has good accuracy and predictive value in determining lymph node status. SUV of the tumor mass is prognostic for overall survival. SUV of the lymph node is prognostic for ECE and also for distant recurrence. Patients with higher lymph node SUVs treated with definitive radiation may warrant higher radiotherapy doses to overcome a greater likelihood of ECE. Nodal SUV may be used to predict patients who would be more likely to benefit from induction chemotherapy.


  1. Jemal A, Siegal R, Ward R, Hao Y, Xu J, Murray T, Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 2008, 58: 71-96. 10.3322/CA.2007.0010.

    Article  PubMed  Google Scholar 

  2. Seiwert TY, Salama JK, Vokes EE: The chemoradiation paradigm in head and neck cancer. Nat Clin Pract Oncol. 2007, 4: 156-171. 10.1038/ncponc0750.

    Article  CAS  PubMed  Google Scholar 

  3. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, Ove R, Kies MS, Baselga J, Youssoufian H, Amellal N, Rowinsky EK, Ang KK: Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006, 354: 567-578. 10.1056/NEJMoa053422.

    Article  CAS  PubMed  Google Scholar 

  4. Poeppel TD, Krause BJ, Heusner TA, Boy C, Bockisch A, Antoch G: PET/CT for the staging and follow-up of patients with malignancies. Eur J Radiol. 2009, 70: 382-92. 10.1016/j.ejrad.2009.03.051.

    Article  CAS  PubMed  Google Scholar 

  5. Zanation AM, Sutton DK, Couch ME, Weissler MC, Shockley WW, Shores CG: Use, Accuracy, and Implications for Patient Management of [18F]-2-Fluorodeoxyglucose-Positron Emission/Computerized Tomography for Head and Neck Tumors. Laryngoscope. 2005, 115: 1186-1190. 10.1097/01.MLG.0000163763.89647.9F.

    Article  PubMed  Google Scholar 

  6. Wax MK, Myers LL, Gabalski EC, Husain S, Gona JM, Nabi H: Positron Emission Tomography in the Evaluation of Synchronous Lung Lesions in Patients With Untreated Head and Neck Cancer Arch Otolaryngol Head Neck Surg. 2002, 128: 703-707.

    Google Scholar 

  7. Kim SY, Roh JL, Yeo NK: Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer. Ann Oncol. 2007, 18: 1698-703. 10.1093/annonc/mdm270.

    Article  CAS  PubMed  Google Scholar 

  8. Yen TC, Chang JT, Ng SH, Chang YC, Chan SC, Lin KJ, Lin WJ, Fu YK, Lin CY: The value of 18F-FDG PET in the detection of stage M0 carcinoma of the nasopharynx. J Nucl Med. 2005, 46: 405-10.

    PubMed  Google Scholar 

  9. Murakami R, Uozumi H, Hirai T, Nishimura R, Shiraishi S, Ota K, Murakami D, Tomiguchi S, Oya N, Katsuragawa S, Yamashita Y: Impact of FDGPET/CT imaging on nodal staging for head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2007, 68: 377-382.

    Article  PubMed  Google Scholar 

  10. Adams S, Baum RP, Stuckensen T, Bitter K, Hör G: Prospective comparison of 18F-FDG PET with conventional imaging modalities (CT, MRI, US) in lymph node staging of head and neck cancer. Eur J Nucl Med. 1998, 25: 1255-1260. 10.1007/s002590050293.

    Article  CAS  PubMed  Google Scholar 

  11. Ng SH, Yen TC, Liao CT: 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: A prospective study of 124 patients with histologic correlation. J Nucl Med. 2005, 46: 1136-1143.

    PubMed  Google Scholar 

  12. Hannah A, Scott AM, Tochon-Danguy H, Chan JG, Akhurst T, Berlangieri S, Price D, Smith GJ, Schelleman T, McKay WJ, Sizeland A: Evaluation of18 F-fluorodeoxyglucose positron emission tomography and computed tomography with histopathologic correlation in the initial staging of head and neck cancer. Ann Surg. 2002, 236: 208-217. 10.1097/00000658-200208000-00009.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Ng SH, Yen TC, Chang JT, Chan JG, Akhurst T, Berlangieri S, Price D, Smith GJ, Schelleman T, McKay WJ, Sizeland A: Prospective study of [18F]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck. J Clin Oncol. 2006, 24: 4371-6. 10.1200/JCO.2006.05.7349.

    Article  PubMed  Google Scholar 

  14. Civantos FJ, Gomez C, Duque C, Pedroso F, Goodwin WJ, Weed DT, Arnold D, Moffat F: Sentinel node biopsy in oral cavity cancer: Correlation with PET scan and immunohistochemistry. Head Neck. 2003, 25: 1-9. 10.1002/hed.10213.

    Article  PubMed  Google Scholar 

  15. Hyde NC, Prvulovich E, Newman L, Waddington WA, Visvikis D, Ell P: A new approach to pre-treatment assessment of the N0 neck in oral squamous cell carcinoma: The role of sentinel node biopsy and positron emission tomography. Oral Oncol. 2003, 39: 350-360. 10.1016/S1368-8375(02)00121-5.

    Article  CAS  PubMed  Google Scholar 

  16. Schwartz DL, Ford E, Rajendran J, Yueh B, Coltrera MD, Virgin J, Anzai Y, Haynor D, Lewellyn B, Mattes D, Meyer J, Phillips M, Leblanc M, Kinahan P, Krohn K, Eary J, Laramore GE: FDG-PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2005, 61: 129-136.

    Article  PubMed  Google Scholar 

  17. Stoeckli SJ, Steinert H, Pfaltz M, Schmid S: Is there a role for positron emission tomography with 18F-fluorodeoxyglucose in the initial staging of nodal negative oral and oropharyngeal squamous cell carcinoma. Head Neck. 2002, 24: 345-349. 10.1002/hed.10057.

    Article  PubMed  Google Scholar 

  18. Fleming AJ, Smith SP, Saul CM: Impact of 18-F-2-Fluorodeozyglucose-positron emission tomography/computed tomography on previously untreated head and necak cancer patients. Laryngoscope. 2007, 117: 1173-79. 10.1097/MLG.0b013e31805d017b.

    Article  PubMed  Google Scholar 

  19. Schwartz Dl, Ragendran J, Yueh B, Coltrera MD, Leblanc M, Eary J, Krohn K: FDG-PET prediction of head and neck squamous cell cancer outcomes. Arch Otolaryngol Head Neck Surg. 2004, 130: 1361-7. 10.1001/archotol.130.12.1361.

    Article  PubMed  Google Scholar 

  20. Brun E, Kjellen E, Tennvall J, Ohlsson T, Sandell A, Perfekt R, Perfekt R, Wennerberg J, Strand SE: FDG PET studies during treatment: prediction of therapy outcome in head and neck squamous cell carcinoma. Head Neck. 2002, 24: 127-135. 10.1002/hed.10037.

    Article  PubMed  Google Scholar 

  21. Minn H, Lapela M, Klemi PJ, Grénman R, Leskinen S, Lindholm P, Bergman J, Eronen E, Haaparanta M, Joensuu H: Prediction of survival with fluorine-18-fluorodeoxyglucose and PET in head and neck cancer. J Nucl Med. 1997, 38: 1907-1911.

    CAS  PubMed  Google Scholar 

  22. Halfpenny W, Hain SF, Biassoni L, Maisey MN, Sherman JA, McGurk M: FDG-PET: a possible prognostic factor in head and neck cancer. Br J Cancer. 2002, 86: 512-516. 10.1038/sj.bjc.6600114.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  23. Roh JL, Pae KH, Choi SH, Kim JS, Lee S, Kim SB, Nam SY, Kim SY: 2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx. Eur J Surg Oncol. 2007, 33: 790-5.

    Article  PubMed  Google Scholar 

  24. Kim SY, Roh JL, Kim MR, Kim JS, Choi SH, Nam SY, Lee SW, Kim SB: Use of 18F-FDG PET for primary treatment strategy in patients with squamous cell carcinoma of the oropharynx. J Nucl Med. 2007, 48: 752-7. 10.2967/jnumed.107.039610.

    Article  PubMed  Google Scholar 

  25. Allal AS, Slosman DO, Kebdani T, Allaoua M, Lehmann W, Dulguerov P: Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-D-glucose. Int J Radiat Oncol Biol Phys. 2004, 59: 1295-300.

    Article  CAS  PubMed  Google Scholar 

  26. Greven KM, Williams DW, McGuirt WF, Harkness BA, D'Agostino RB, Keyes JW, Watson NE: Serial positron emission tomography scans following radiation therapy of patients with head and neck cancer. Head Neck. 2001, 23: 942-6. 10.1002/hed.1136.

    Article  CAS  PubMed  Google Scholar 

  27. Liao CT, Chang JT, Wang HM, Ng SH, Hsueh C, Lee LY, Lin CH, Chen IH, Huang SF, Cheng AJ, Yen TC: Preoperative [18F] fluorodeoxyglucose positron emission tomography standardized uptake value of neck lymph nodes predicts neck cancer control and survival rates in patients with oral cavity squamous cell carcinoma and pathologically positive lymph nodes. Int J Radiat Oncol Biol Phys. 2009, 74: 1054-61.

    Article  PubMed  Google Scholar 

  28. Kyzas P, Evangelou E, Denaxa-Kyza D, Ioannidis JP: 18-F-Flurodeoxyglucose positron emission tomography to evaluate cervical node metastases in patietns with head and neck squamous cell carcinoma: A meta-analysis. J Natl Can Inst. 2008, 100: 712-20. 10.1093/jnci/djn125.

    Article  Google Scholar 

  29. Yao M, Nguyen T, Dornfeld KJ: Prognostic Significance of FDG PET for Head and Neck Cancer Treated with IMRT. Int J Radiat Oncol Biol Phys. 2005, S1 (63): S149-S150.

    Article  Google Scholar 

  30. Branstetter B, Blodgett T, Zimmer L, Snyderman CH, Johnson JT, Raman S, Meltzer CC: Head and neck malignancy: is PET/CT more accurate than PET or CT alone?. Radiology. 2005, 235: 580-586. 10.1148/radiol.2352040134.

    Article  PubMed  Google Scholar 

  31. Endo K, Oriuchi N, Higuchi T, Iida Y, Hanaoka H, Miyakubo M, Ishikita T, Koyama K: PET and PET/CT using 18F-FDG in the diagnosis and management of cancer patients. Int J Clin Oncol. 2006, 4: 286-296. 10.1007/s10147-006-0595-0.

    Article  Google Scholar 

  32. Schoder H, Yeung H, Gonen M, Kraus D, Larson SM: Head and neck cancer: clinical usefulness and accuracy of PET/CT image fusion. Radiology. 2004, 231: 66-72. 10.1148/radiol.2311030271.

    Article  Google Scholar 

  33. Machtay M, Moughan J, Trotti A, Garden AS, Weber RS, Cooper JS, Forastiere A, Ang KK: Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol. 2008, 26: 3582-9. 10.1200/JCO.2007.14.8841.

    Article  CAS  PubMed  Google Scholar 

  34. Posner MR, Hershock Dm, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V, Tjulandin S, Shin DM, Cullen K, Ervin TJ, Murphy BA, Raez LE, Cohen RB, Spaulding M, Tishler RB, Roth B, Viroglio Rdel C, Venkatesan V, Romanov I, Agarwala S, Harter KW, Dugan M, Cmelak A, Markoe AM, Read PW, Steinbrenner L, Colevas AD, Norris CM, Haddad RI: Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med. 2007, 357: 1705-15. 10.1056/NEJMoa070956.

    Article  CAS  PubMed  Google Scholar 

  35. Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M, Stewart JS, Jelic S, Betka J, Preiss JH, van den Weyngaert D, Awada A, Cupissol D, Kienzer HR, Rey A, Desaunois I, Bernier J, Lefebvre JL: Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med. 2007, 357: 1695-704. 10.1056/NEJMoa071028.

    Article  CAS  PubMed  Google Scholar 

  36. Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL: Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005, 27: 843-50. 10.1002/hed.20279.

    Article  PubMed  Google Scholar 

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Information was presented at the 2008 ASTRO annual meeting

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GK: wrote manuscript, data analysis, CC: data retrieval and chart review, SF: edited manuscript, assistance with data analysis, FW: edited manuscript, ER: edited manuscript, CI: edited manuscript, RD: edited manuscript, MM: edited manuscript, project design. All authors read and approved the final manuscript

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Kubicek, G.J., Champ, C., Fogh, S. et al. FDG-PET staging and importance of lymph node SUV in head and neck cancer. Head Neck Oncol 2, 19 (2010).

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