Table 5 Univariate and multivariate analysis of factors affecting cause specific survival
From: Definitive radiotherapy for early stage glottic cancer by 6 MV photons
T1N0 | T2N0 | |||||||
|---|---|---|---|---|---|---|---|---|
Parameters | Event/pts | Uni-variate | Multivariate analysis | Event/pts | Uni-variate | Multivariate analysis | ||
P value | Hazard ratio (95% CI) | P value | P value | Hazard ratio (95%CI) | P value | |||
Age | ||||||||
<61 | 4/142 | 0.897 | - | NS | 0/90 | 0.224 | - | NS |
61-70 | 3/153 | 3/103 | ||||||
>70 | 3/138 | 2/69 | ||||||
Sex | ||||||||
Male | 10/413 | 0.459 | - | NS | 5/249 | 0.61 | - | NS |
Female | 0/20 | 0/13 | ||||||
Substage | ||||||||
T1A | 7/324 | 0.53 | - | NS | NA | - | - | - |
T1B | 3/109 | |||||||
Grade | ||||||||
Well diff | 3/154 | 0.825 | - | NS | 1/63 | 0.721 | NS | |
Mod diff | 7/273 | 3/179 | ||||||
Poorly diff | 0/6 | 1/20 | ||||||
Impaired Cord mobility | ||||||||
yes | NA | - | - | - | 1/51 | 0.84 | NS | |
No | 4/211 | |||||||
Subglottic Extension | ||||||||
Yes | NA | - | - | - | 2/80 | 0.56 | - | NS |
No | 3/182 | |||||||
Hb (g/ dL) | ||||||||
< 13.0 | 1/45 | 0.76 | - | NS | 1/28 | 0.022* | 2.8 (1.5-7.8) | 0.028* |
≥ 13.0 | 9/388 | 4/234 | 1 | |||||
AC | ||||||||
No | 2/236 | 0.026* | 1 | 0.045* | 1/76 | 0.712 | - | NS |
Yes | 8/197 | 3.7 (1.20-18.5) | 4/186 | |||||
Field size (cm2) | ||||||||
<30.5 | 6/217 | 0.642 | - | NS | 0 | 0.42 | - | NS |
30.5- 35.5 | 4/165 | 2/106 | ||||||
> 35.5 | 0/53 | 3/156 | ||||||
Dose size | ||||||||
2.0 Gy | 7/256 | 0.463 | - | NS | 4/176 | 0.513 | - | NS |
2.5 Gy | 3/177 | 1/86 | ||||||
BED Gy15 | ||||||||
< 65.0 | 8/315 | 0.661 | - | NS | 4/175 | 0.534 | - | NS |
≥ 65.0 | 2/118 | 1/87 | ||||||
Tx period | ||||||||
1983- 1990 | 1/115 | 0.287 | - | NS | 0/75 | 0. 334 | - | NS |
1991- 2000 | 6/224 | 4/142 | ||||||
2001- 2005 | 3/94 | 1/45 | ||||||