Skip to main content

Table 5 Univariate and multivariate analysis of factors affecting cause specific survival

From: Definitive radiotherapy for early stage glottic cancer by 6 MV photons

T1N0 T2N0
Parameters Event/pts Uni-variate Multivariate analysis Event/pts Uni-variate Multivariate analysis
P value Hazard ratio (95% CI) P value   P value Hazard ratio (95%CI) P value
Age         
<61 4/142 0.897 - NS 0/90 0.224 - NS
61-70 3/153     3/103    
>70 3/138     2/69    
Sex         
Male 10/413 0.459 - NS 5/249 0.61 - NS
Female 0/20     0/13    
Substage         
T1A 7/324 0.53 - NS NA - - -
T1B 3/109        
Grade         
Well diff 3/154 0.825 - NS 1/63 0.721   NS
Mod diff 7/273     3/179    
Poorly diff 0/6     1/20    
Impaired Cord mobility         
yes NA - - - 1/51 0.84   NS
No      4/211    
Subglottic Extension         
Yes NA - - - 2/80 0.56 - NS
No      3/182    
Hb (g/ dL)         
< 13.0 1/45 0.76 - NS 1/28 0.022* 2.8 (1.5-7.8) 0.028*
≥ 13.0 9/388     4/234   1  
AC         
No 2/236 0.026* 1 0.045* 1/76 0.712 - NS
Yes 8/197   3.7 (1.20-18.5)   4/186    
Field size (cm2)         
<30.5 6/217 0.642 - NS 0 0.42 - NS
30.5- 35.5 4/165     2/106    
> 35.5 0/53     3/156    
Dose size         
2.0 Gy 7/256 0.463 - NS 4/176 0.513 - NS
2.5 Gy 3/177     1/86    
BED Gy15         
< 65.0 8/315 0.661 - NS 4/175 0.534 - NS
≥ 65.0 2/118     1/87    
Tx period         
1983- 1990 1/115 0.287 - NS 0/75 0. 334 - NS
1991- 2000 6/224     4/142    
2001- 2005 3/94     1/45    
  1. Abbreviations: pts = patients; Hb = hemoglobin; Tx = treatment; diff = differentiated AC = anterior commissure; BED = biologically effective dose; * = statistically significant; NS = not significant.