| |
Overall Cohort (n = 96)
|
Definitive SBRT Subgroup (n = 89)
|
|---|
| |
Univariate
|
Multivariate
|
Univariate
|
Multivariate
|
|---|
| |
p
|
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
HR (95% CI)
|
|---|
|
PET-CT Planning
|
0.640
|
1.1 (0.72, 1.71)
|
0.708
|
Not entered
|
0.657
|
0.91 (0.58, 1.41)
|
0.960
|
Not entered
|
|
Tumor volume (5 cc increase)
|
0.036
|
1.03 (1.001, 1.06)
|
0.030
|
1.04 (1.006, 1.07)
|
0.025
|
1.03 (1.001, 1.06)
|
0.024
|
1.04 (1.006, 1.07)
|
|
Cetuximab with SBRT
|
0.192
|
1.36 (0.86, 2.14)
|
0.431
|
Not entered
|
0.700
|
1.10 (0.69, 1.74)
|
0.827
|
Not entered
|
|
Interval from previous radiation to recurrence (3 month increase)
|
| |
0.731
|
0.997 (0.97, 1.02)
|
0.475
|
Not entered
|
0.845
|
0.997 (0.98, 1.01)
|
0.433
|
Not entered
|
|
Any In-field/Overlap/Marginal failure
|
| |
0.141
|
1.39 (0.90, 2.15)
|
0.025
|
1.71 (1.07, 2.74)
|
0.547
|
1.15 (0.74, 1.78)
|
0.095
|
1.50 (0.93, 2.43)
|
|
Age (10 year increase)
|
0.273
|
1.11 (0.93, 1.32)
|
0.021
|
1.25 (1.04, 1.49)
|
0.128
|
1.15 (0.96, 1.37)
|
0.012
|
1.27 (1.05, 1.54)
|
|
Any Prior Surgery
|
0.007
|
0.50 (0.30, 0.83)
|
0.004
|
0.46 (0.27, 0.78)
|
0.023
|
0.55 (0.33, 0.92)
|
0.010
|
0.49 (0.29, 0.85)
|
|
KPS (10 KPS increase)
|
0.010
|
0.80 (0.69, 0.94)
|
0.007
|
0.79 (0.66, 0.94)
|
0.041
|
0.84 (0.71, 0.99)
|
0.028
|
0.82 (0.69, 0.98)
|
|
Any distant metastases or untreated locoregional disease
|
| |
0.004
|
1.95 (1.24, 3.07)
|
0.016
|
1.80 (1.12, 2.90)
|
0.024
|
1.69 (1.07, 2.67)
|
0.037
|
1.66 (1.03, 2.69)
|
- Abbreviations: SBRT = stereotactic body radiation therapy, HR = hazard ratio for death, CI = confidence interval, KPS = Karnofsky performance status.
