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Table 6 Cox regression analysis for overall survival

From: A retrospective, deformable registration analysis of the impact of PET-CT planning on patterns of failure in stereotactic body radiation therapy for recurrent head and neck cancer

 

Overall Cohort (n = 96)

Definitive SBRT Subgroup (n = 89)

 

Univariate

Multivariate

Univariate

Multivariate

 

p

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

PET-CT Planning

0.640

1.1 (0.72, 1.71)

0.708

Not entered

0.657

0.91 (0.58, 1.41)

0.960

Not entered

Tumor volume (5 cc increase)

0.036

1.03 (1.001, 1.06)

0.030

1.04 (1.006, 1.07)

0.025

1.03 (1.001, 1.06)

0.024

1.04 (1.006, 1.07)

Cetuximab with SBRT

0.192

1.36 (0.86, 2.14)

0.431

Not entered

0.700

1.10 (0.69, 1.74)

0.827

Not entered

Interval from previous radiation to recurrence (3 month increase)

 

0.731

0.997 (0.97, 1.02)

0.475

Not entered

0.845

0.997 (0.98, 1.01)

0.433

Not entered

Any In-field/Overlap/Marginal failure

 

0.141

1.39 (0.90, 2.15)

0.025

1.71 (1.07, 2.74)

0.547

1.15 (0.74, 1.78)

0.095

1.50 (0.93, 2.43)

Age (10 year increase)

0.273

1.11 (0.93, 1.32)

0.021

1.25 (1.04, 1.49)

0.128

1.15 (0.96, 1.37)

0.012

1.27 (1.05, 1.54)

Any Prior Surgery

0.007

0.50 (0.30, 0.83)

0.004

0.46 (0.27, 0.78)

0.023

0.55 (0.33, 0.92)

0.010

0.49 (0.29, 0.85)

KPS (10 KPS increase)

0.010

0.80 (0.69, 0.94)

0.007

0.79 (0.66, 0.94)

0.041

0.84 (0.71, 0.99)

0.028

0.82 (0.69, 0.98)

Any distant metastases or untreated locoregional disease

 

0.004

1.95 (1.24, 3.07)

0.016

1.80 (1.12, 2.90)

0.024

1.69 (1.07, 2.67)

0.037

1.66 (1.03, 2.69)

  1. Abbreviations: SBRT = stereotactic body radiation therapy, HR = hazard ratio for death, CI = confidence interval, KPS = Karnofsky performance status.