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Table 6 Cox regression analysis for overall survival

From: A retrospective, deformable registration analysis of the impact of PET-CT planning on patterns of failure in stereotactic body radiation therapy for recurrent head and neck cancer

  Overall Cohort (n = 96) Definitive SBRT Subgroup (n = 89)
  Univariate Multivariate Univariate Multivariate
  p HR (95% CI) p HR (95% CI) p HR (95% CI) p HR (95% CI)
PET-CT Planning 0.640 1.1 (0.72, 1.71) 0.708 Not entered 0.657 0.91 (0.58, 1.41) 0.960 Not entered
Tumor volume (5 cc increase) 0.036 1.03 (1.001, 1.06) 0.030 1.04 (1.006, 1.07) 0.025 1.03 (1.001, 1.06) 0.024 1.04 (1.006, 1.07)
Cetuximab with SBRT 0.192 1.36 (0.86, 2.14) 0.431 Not entered 0.700 1.10 (0.69, 1.74) 0.827 Not entered
Interval from previous radiation to recurrence (3 month increase)
  0.731 0.997 (0.97, 1.02) 0.475 Not entered 0.845 0.997 (0.98, 1.01) 0.433 Not entered
Any In-field/Overlap/Marginal failure
  0.141 1.39 (0.90, 2.15) 0.025 1.71 (1.07, 2.74) 0.547 1.15 (0.74, 1.78) 0.095 1.50 (0.93, 2.43)
Age (10 year increase) 0.273 1.11 (0.93, 1.32) 0.021 1.25 (1.04, 1.49) 0.128 1.15 (0.96, 1.37) 0.012 1.27 (1.05, 1.54)
Any Prior Surgery 0.007 0.50 (0.30, 0.83) 0.004 0.46 (0.27, 0.78) 0.023 0.55 (0.33, 0.92) 0.010 0.49 (0.29, 0.85)
KPS (10 KPS increase) 0.010 0.80 (0.69, 0.94) 0.007 0.79 (0.66, 0.94) 0.041 0.84 (0.71, 0.99) 0.028 0.82 (0.69, 0.98)
Any distant metastases or untreated locoregional disease
  0.004 1.95 (1.24, 3.07) 0.016 1.80 (1.12, 2.90) 0.024 1.69 (1.07, 2.67) 0.037 1.66 (1.03, 2.69)
  1. Abbreviations: SBRT = stereotactic body radiation therapy, HR = hazard ratio for death, CI = confidence interval, KPS = Karnofsky performance status.