The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck

Chau, Nicole G; Perez-Ordonez, Bayardo; Zhang, Katherine; Pham, Nhu-An; Ho, James; Zhang, Tong; Ludkovski, Olga; Wang, Lisa; Chen, Eric X; Tsao, Ming-Sound; Kamel-Reid, Suzanne; Siu, Lillian L

doi:10.1186/1758-3284-3-11

Table 2 EGFRvIII mutation positive detected by RT-PCR (n = 22)

From: The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck

Case	Treatment	Primary Site	Specimen Site	EGFRvIII by RT-PCR	EGFRvIII Fold Changes	HPV DNA by Linear Array	P16 IHC	MET score by IHC	EGFR FISH
1	Erlotinib	hypopharynx	Untreated primary	+	11.33	-	-	High	Low polysomy
2	Erlotinib	oral cavity	Untreated primary	+	7.01	-	-	High	Disomy
3	Erlotinib	larynx	Untreated primary	+	61.77	-	-	Low	Low polysomy
4	Erlotinib	larynx	Local recurrence	+	26.64	-	-	Low	High polysomy
5	Erlotinib	neck mass unknown primary	Untreated lymph node	+	60.04	33 +	+	High	Low trisomy
6	Erlotinib	oral cavity	Untreated lymph node	+	218.49	-	-	High	Amplification
7	Erlotinib	oropharynx	Unknown primary	+	15.66	16 +	+	High	Low trisomy
8	Erlotinib	oral cavity	Local recurrence	+	8.94	-	-	High	Low polysomy
9	Erlotinib + Cisplatin	neck mass unknown primary	Untreated lymph node	+	127.84	16+	NE	NE	Low trisomy
10	Erlotinib + Cisplatin	larynx	Node recurrence	+	576.36	16+	+	High	Disomy
11	Erlotinib + Cisplatin	larynx	Untreated primary	+	8.26	-	-	Low	Failed
12	Erlotinib + Cisplatin	larynx	Untreated primary	+	17.38	-	-	High	Low polysomy
13	Erlotinib + Cisplatin	oropharynx	Untreated primary	+	14.28	16+	+	High	Disomy
14	Erlotinib + Cisplatin	oral cavity	Untreated primary	+	69.68	-	NE	NE	Low polysomy
15	Erlotinib + Cisplatin	oral cavity	Untreated primary	+	11.11	53+, 58+, 6+, 52+	-	High	Low polysomy
16	Sorafenib	oropharynx	Untreated primary	+	7.71	16 +	+	Low	Low polysomy
17	Sorafenib	oropharynx	Untreated primary	+	7.93	16 +	+	Low	Low trisomy
18	Ispinesib	neck mass unknown primary	Untreated lymph node	+	4.12	16+, 53+, 51 +	+	High	High polysomy
19	Ispinesib	oropharynx	Untreated primary	+	15.61	16+, 53+, 33+, 51+, 58 +	-	High	High polysomy
20	Ispinesib	larynx	Untreated primary	+	218.26	-	-	High	Disomy
21	Ispinesib	oropharynx	Local recurrence	+	29.25	16+, 53+, 51+	+	Low	Disomy
22	Ispinesib	hypopharynx	Local recurrence	+	9.31	16+, 53+, 58+, 52+	-	High	Low polysomy

Abbreviations: +, positive; -, negative; NE, not evaluable

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Head & Neck Oncology