Volume 2 Supplement 1

2nd Scientific Meeting of the Head and Neck Optical Diagnostics Society

Open Access

Assessment of suspicious oral lesions using optical coherence tomography

  • Zaid Hamdoon1,
  • Waseem Jerjes1,
  • Gordon McKenzie1,
  • Amrita Jay1 and
  • Colin Hopper1
Head & Neck Oncology20102(Suppl 1):O6

https://doi.org/10.1186/1758-3284-2-S1-O6

Published: 29 October 2010

Introduction/aims

Optical biopsy systems have been investigated for various clinical applications; however the main interest remains in the diagnosis and monitoring of premalignant and malignant conditions. In this study, we compared findings of optical coherence tomography (OCT) with histopathology results of suspicious oral lesions to assess the feasibility of OCT in identifying pathological tissue.

Material/methods

Suspicious oral lesions acquired from 120 patients were subjected to immediate ex-vivo Swept-Source Frequency-Domain OCT. Five OCT parameters were assessed (keratin, epithelial, sub-epithelial layers changes, basement membrane and microanatomical structures). Two clinicians and two pathologists, who were blind to clinical and histopathological diagnosis, examined the OCT images autonomously, provided deferential diagnosis, the most probable diagnosis and provided judgment on the need for surgical biopsy. Inter, Intra-observer differences, sensitivity and specificity was calculated.

Results/statistics

Basic microanatomical tissue structures were identified on the mainstream of the OCT images. Recognition of the basement membrane was achieved in the majority of the lesions. Identification of changes in the parameters ruled areas of architectural changes. There was a high inter and intra-observer agreement among the two clinicians and two pathologists, who recommended a surgical biopsy when examined all the histologically proven dysplasia and cancer OCT images. Sensitivity and specificity were calculated and proved to be encouraging.

Conclusions/clinical relevance

At this phase, OCT can definitely aide clinical examination and monitoring and can be invaluable tool for inexperienced clinicians.

Declarations

Acknowledgment

We would like to thank the BAOMS for supporting this research project.

Authors’ Affiliations

(1)
UCL Department of Surgery, University College London Medical School

Copyright

© Hamdoon et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.