- Oral presentation
- Open Access
- Published:
Assessment of suspicious oral lesions using optical coherence tomography
Head & Neck Oncology volume 2, Article number: O6 (2010)
Introduction/aims
Optical biopsy systems have been investigated for various clinical applications; however the main interest remains in the diagnosis and monitoring of premalignant and malignant conditions. In this study, we compared findings of optical coherence tomography (OCT) with histopathology results of suspicious oral lesions to assess the feasibility of OCT in identifying pathological tissue.
Material/methods
Suspicious oral lesions acquired from 120 patients were subjected to immediate ex-vivo Swept-Source Frequency-Domain OCT. Five OCT parameters were assessed (keratin, epithelial, sub-epithelial layers changes, basement membrane and microanatomical structures). Two clinicians and two pathologists, who were blind to clinical and histopathological diagnosis, examined the OCT images autonomously, provided deferential diagnosis, the most probable diagnosis and provided judgment on the need for surgical biopsy. Inter, Intra-observer differences, sensitivity and specificity was calculated.
Results/statistics
Basic microanatomical tissue structures were identified on the mainstream of the OCT images. Recognition of the basement membrane was achieved in the majority of the lesions. Identification of changes in the parameters ruled areas of architectural changes. There was a high inter and intra-observer agreement among the two clinicians and two pathologists, who recommended a surgical biopsy when examined all the histologically proven dysplasia and cancer OCT images. Sensitivity and specificity were calculated and proved to be encouraging.
Conclusions/clinical relevance
At this phase, OCT can definitely aide clinical examination and monitoring and can be invaluable tool for inexperienced clinicians.
Acknowledgment
We would like to thank the BAOMS for supporting this research project.
Author information
Affiliations
Corresponding author
Rights and permissions
Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Hamdoon, Z., Jerjes, W., McKenzie, G. et al. Assessment of suspicious oral lesions using optical coherence tomography. Head Neck Oncol 2, O6 (2010). https://doi.org/10.1186/1758-3284-2-S1-O6
Published:
Keywords
- Basement Membrane
- Optical Coherence Tomography
- Optical Coherence Tomography Image
- Histopathology Result
- Invaluable Tool
