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Head & Neck Oncology

Open Access

Towards early dental caries detection with OCT and polarized Raman spectroscopy

  • Lin-P'ing Choo-Smith1, 2,
  • Mark Hewko1 and
  • Michael Sowa1
Head & Neck Oncology20102(Suppl 1):O43

https://doi.org/10.1186/1758-3284-2-S1-O43

Published: 29 October 2010

In recent years, we have been developing optical coherence tomography (OCT) and polarized Raman spectroscopy (PRS) for the detection of early non-cavitated dental caries. OCT provides high resolution morphological depth imaging of incipient caries. With OCT, early lesions can be readily identified as regions of high light backscattering with depth into the enamel as compared to health sound enamel. From the OCT images, the lesion depth can be approximated to provide clinically useful information to guide treatment decisions. In addition, we have derived a parameter known as the optical attenuation coefficient in order to distinguish sound from carious enamel non-subjectively. OCT is being combined with PRS since regions of high light backscattering not related to caries development can lead to false-positive results. PRS provides biochemical specificity along with molecular structural/orientational information. With PRS, the Raman depolarization ratio calculated from the main phosphate vibration at ~959 cm-1 from parallel- and cross-polarized Raman spectra allows discrimination between sound and early developing caries. Early studies on lab bench instrumentation are now being translated into fibre-optic based devices for intra-oral use in patient volunteers for clinical validation. In combination, OCT and PRS have potential for detecting and monitoring early lesions with high sensitivity and high specificity.

Authors’ Affiliations

(1)
Institute for Biodiagnostics, National Research Council Canada
(2)
Dept. Restorative Dentistry, Faculty of Dentistry, University of Manitoba

Copyright

© Choo-Smith et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.

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