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Photodynamic therapy as the "last hope" for tongue-based carcinoma
Head & Neck Oncology volume 2, Article number: O27 (2010)
The management of base of tongue carcinoma continue to be a major challenge in head and neck oncology. Our aim in this prospective study was to evaluate the outcome following ultrasound-guided interstitial photodynamic therapy (US-iPDT) of stage IV tongue base carcinoma. Patients’ reports on quality of life with clinical and radiological evaluation were the main end point parameters used to assess the outcome.
Thirty-three consecutive patients were referred to the UCLH Head and Neck Centre for treatment of advanced tongue base cancer. Two-thirds of the patients had not been offered further treatment. It was decided that the only available option is to offer US-iPDT under general anaesthesia, using mTHPC as the photosensitising agent. Following treatment, patients were followed-up for a mean of 18 months (Min 8, Max 44).
11/14 patients who presented with breathing problems reported improvement after treatment. Also, 28/33 reported improvement of swallowing. Improvement of speaking was reported by 15/18 patients.
Clinical assessment showed that two-thirds of the patients had “good response” to the treatment and a third reported “moderate response”. Radiological assessment comparing imaging 6-week post-PDT to the baseline showed stable pathology with no change in size in 6 patients, minimal response in 7 patients, moderate response in 12 patients and significant response in 5 patients.
Eleven patients died; Seven of which due to locoregional metastasis. Kaplan-Meir survival curve was generated from the survival and follow-up data.
Photodynamic therapy is a successful palliative modality in the treatment of advanced tongue base carcinoma.
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Jerjes, W., Upile, T., Hamdoon, Z. et al. Photodynamic therapy as the "last hope" for tongue-based carcinoma. Head Neck Oncol 2, O27 (2010) doi:10.1186/1758-3284-2-S1-O27
- Significant Response
- Photodynamic Therapy
- Radiological Evaluation
- Radiological Assessment
- Moderate Response