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Head & Neck Oncology

Open Access

Using optical coherence tomography to monitor effects of electromechanical reshaping in septal cartilage

  • Heather Chen1,
  • Lingfeng Yu1,
  • Cyrus Manuel1 and
  • Brian Jet-Fei Wong1
Head & Neck Oncology20102(Suppl 1):O19

https://doi.org/10.1186/1758-3284-2-S1-O19

Published: 29 October 2010

Electromechanical reshaping (EMR) of cartilage is a promising noninvasive technique with potential for broad application in reconstructive surgery. EMR involves applying direct current electrical fields to localized stress regions and then initiating a series of oxidation-reduction reactions, thus effecting a shape change. Previous EMR studies have focused on macroscopic structural measurements of the shape change effect or monitoring of electrical current flow. Only limited investigation of structural changes in the tissue at the histologic level have been performed, and not in real time. This study is the first to use optical coherence tomography (OCT) to examine structural changes in cartilage during EMR. Two platinum needle electrodes were inserted into fixed rectangular rabbit nasal septal cartilage specimens. The spectral domain OCT probe was then positioned above the anode needle. A constant voltage of 6V was applied for 3 minutes, and images were obtained (8 frames/second). OCT was also performed in specimens undergoing dehydration under ambient conditions and during pH changes produced by the addition of HCl, as both processes accompany EMR. The OCT data identified distinct findings among the three conditions, suggesting that EMR causes a much greater degree of reshaping on a molecular level than dehydration or a change in pH alone. OCT provides a means to gauge structural changes in the tissue matrix during EMR. The application of OCT to image the EMR process will add to our understanding of the mechanisms of action involved and potentially facilitate optimization of this process.

Authors’ Affiliations

(1)
University of California

Copyright

© Yu et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.

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