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Table 3 Relationship among clinicopathological factors and marker expression patterns

From: Prognostic Significance of Nuclear Survivin Expression in Resected Adenoid Cystic Carcinoma of the Head and Neck

 

C-survivin*

N-survivin†

 

Low, n(%)

High, n(%)

P-value

Low, n(%)

High, n(%)

P-value

Histological growth pattern

      

   Tubular, cribriform

6(100)

24(77.4)

0.255

12 (85.7)

18(78.3)

0.459

   Solid

0(0)

7(22.6)

 

2(14.3)

5(21.7)

 

Grade

      

   Well, moderately

5(83.3)

22(71.0)

0.475

12 (85.7)

15(65.2)

0.164

   Poorly

1(16.7)

9(29.0)

 

2(14.3)

8(34.8)

 

Stage

      

   I, II

4(66.7)

15(48.4)

0.357

10(71.4)

9(39.1)

0.357

   III, IV

2(33.3)

16(51.6)

 

2(28.6)

14(51.6)

 

Tumor size

      

   ≤ 3 cm

5(83.3)

9(34.6)

0.043‡

8(61.5)

11(42.1)

0.057

   > 3 cm

1(16.7)

17(65.4)

 

5(38.5)

8(57.9)

 

Lymph node involvement

      

   Negative

6(100)

27(87.1)

0.476

6(46.2)

11(87)

0.821

   Positive

0(0)

4(10.8)

 

7(53.8)

3(13)

 

Bcl-2

      

   Negative

5(83.3)

13(41.9)

0.078

10(71.4)

8(34.8)

0.031‡

   Positive

1(16.7)

18(58.1)

 

4(28.6)

15(65.2)

 

Ki-67

      

   Negative

6(100)

27(87.1)

0.476

13(92.9)

20(87)

0.509

   Positive

0(0)

4(12.9)

 

1(7.1)

3(13)

 

P53

      

   Negative

5(83.3)

23(74.2)

0.543

12(85.7)

16(69.6)

0.267

   Positive

1(16.7)

8(25.8)

 

2(14.3)

7(30.4)

 
  1. * cytoplasmic survivin
  2. † nuclear survivin
  3. ‡ statistically significant (P < 0.05)