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Table 3 Relationship among clinicopathological factors and marker expression patterns

From: Prognostic Significance of Nuclear Survivin Expression in Resected Adenoid Cystic Carcinoma of the Head and Neck

  C-survivin* N-survivin
  Low, n(%) High, n(%) P-value Low, n(%) High, n(%) P-value
Histological growth pattern       
   Tubular, cribriform 6(100) 24(77.4) 0.255 12 (85.7) 18(78.3) 0.459
   Solid 0(0) 7(22.6)   2(14.3) 5(21.7)  
Grade       
   Well, moderately 5(83.3) 22(71.0) 0.475 12 (85.7) 15(65.2) 0.164
   Poorly 1(16.7) 9(29.0)   2(14.3) 8(34.8)  
Stage       
   I, II 4(66.7) 15(48.4) 0.357 10(71.4) 9(39.1) 0.357
   III, IV 2(33.3) 16(51.6)   2(28.6) 14(51.6)  
Tumor size       
   ≤ 3 cm 5(83.3) 9(34.6) 0.043 8(61.5) 11(42.1) 0.057
   > 3 cm 1(16.7) 17(65.4)   5(38.5) 8(57.9)  
Lymph node involvement       
   Negative 6(100) 27(87.1) 0.476 6(46.2) 11(87) 0.821
   Positive 0(0) 4(10.8)   7(53.8) 3(13)  
Bcl-2       
   Negative 5(83.3) 13(41.9) 0.078 10(71.4) 8(34.8) 0.031
   Positive 1(16.7) 18(58.1)   4(28.6) 15(65.2)  
Ki-67       
   Negative 6(100) 27(87.1) 0.476 13(92.9) 20(87) 0.509
   Positive 0(0) 4(12.9)   1(7.1) 3(13)  
P53       
   Negative 5(83.3) 23(74.2) 0.543 12(85.7) 16(69.6) 0.267
   Positive 1(16.7) 8(25.8)   2(14.3) 7(30.4)  
  1. * cytoplasmic survivin
  2. nuclear survivin
  3. statistically significant (P < 0.05)