Skip to content


You're viewing the new version of our site. Please leave us feedback.

Learn more

Head & Neck Oncology

Open Access

The effect of smoking, drinking and smoking cessation on morbidity and mortality in oral cancer: a controlled study

  • Jesuloba Abiola1,
  • Waseem Jerjes1,
  • Tahwinder Upile1,
  • Farai Nhembe1,
  • Priya Shah1 and
  • Colin Hopper1
Head & Neck Oncology20091(Suppl 1):P18

Published: 28 July 2009


Smoking and Alcohol have been implicated in the development and maintenance of squamous cell carcinoma with an almost synergistic effect. We review the effect and timing of smoking, drinking and smoking cessation upon the peri-operative morbidity and mortality for oral cancer surgery.

Materials and methods

A controlled cohort involved 67 patients who were diagnosed with oral squamous cell carcinoma. The smoking and drinking habits of this groups was recorded, in addition cessation of smoking after diagnosis was assessed; these were compared to TNM, depth of invasion, pattern of invasion, dysplasia at margin, vascular and nerve invasion, recurrence, 3 and 5 years survival and cause of death.


Smokers are nearly twice as likely to suffer worsened prognosis as non smokers with ex-smokers in an intermediate deleterious position (p < 0.01). Alcohol is associated with a detrimental effect but the effect was not significant, this may be due to the small sample size.


Smoking does have an adverse effect on peri-operative outcome and eventual prognosis. We would commend patients to stop smoking to improve outcomes especially during treatment (i.e. surgery or radiotherapy).

Authors’ Affiliations

UCLH Head & Neck Centre


© Abiola et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.