Aim of study
Early diagnosis of cancerous lesions renders them suitable for minimally invasive therapy. Photochemical internalisation (PCI) is a new technique which involves sub-lethal photodynamic treatment to modify the intracellular distribution of co-administered drugs and other agents which are sequestered in lyso/endosomes. In this study, we investigated the PCI effect induced by a new photosensitiser, TPCS2a, in combination with a cytotoxic macromolecular drug, saporin, both in vitro and in vivo.