Role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review

Table 3 Prevalence of HPV in malignant lesions of the Head and neck

Study	Year	Types of Lesion	Method	Positive/cases	%	HPV type
Zeuss et al [87]	1991	SCC	ISH	0/15	0	-
Holladay & Gerald [88]	1993	SCC	PCR	7/37	19	16 & 18
Ostwald et al [94]	1994	SCC	PCR/SB	16/26	62	16 (45%), 18 (35%) 6, 11 (15%)
Balaram et al [95]	1995	SCC	PCR	67/91	74	6(13%), 11(20%), 16 (42%)
Cruz et al [96]	1996	SCC	PCR	19/35	55	16(79%)
Wilczynski et al [97]	1998	SCC	PCR	14/21	64	16(80%), 33(10%), 59(10%)
Bustos et al [98]	1999	SCC	ISH	09/33	27	16
van Houten et al [99]	2001	HNSCC	PCR & T-PCR	84	-	High Risk HPV
Kojima et al [100]	2002	SCC	PCR	35/53	66	38
Sugiyama et al [101]	2003	SCC	PCR	30/86	35	16
Smith et al [31]	2004	SCC	PCR	38/201	19	16
Koppikar et al [69]	2005	SCC	PCR	6/102	6	16,18
Slebos et al [102]	2006	SCC	RT-PCR	8/36	22	16
Luo et al [67]	2007	SCC	PCR	11/51	73	-
Zhang et al [103]	2008	SCC	ISH	10/30	33	-
Chuang et al [104]	2008	SCC	RT-PCR	20/59	33.9	16
Simonato et al[105]	2008	SCC	-	5/29	17.2	nested PCR
Richards et al [106]	2009	HNSCC	LOH	-	-	-
Gudleviciene et al [107]	2009	HNSCC	-	-	-	16

Abbreviations: *PCR = Polymerase chain reaction, LOH = Loss of heterozygosity, RT-PCR = Real Time PCR, IHC = Immunohistochemistry, SB = Southern Blotting