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Table 1 Summary of the study characteristics

From: Spinal metastasis in thyroid cancer

Study, year

Study design

End point

Bernier et al., 200135

Retrospective cohort analysis

Survival and impact of treatment on survival.

Cabanillas et al., 201036

Prospective intervention

Determine response and progression free survival due to treatment with sorafenib/sunitinib

De Vries et al., 200837

Retrospective cohort analysis

Determine the effect of selective embolisation on serum thyroglobulin and symptoms

Demura et al., 201114

Retrospective cohort analysis

Determine the effect of total en bloc spondylectomy on survival and local recurrence

Durante et al., 200631

Retrospective cohort analysis

Determine the response and effect on survival of 131I therapy

Eustatia-Rutten et al., 200317

Retrospective cohort analysis

Determine the effect of palliative embolisation on clinical symptoms.

Hindie í et al., 200715

Observational study

To investigate the impact of early 131I-based detection on outcome.

Kloos et al., 200938

Phase II Trial

Objective response rate of VEGFR inhibitors

Orita et al., 201116

Retrospective cohort analysis

Determine the efficacy of zolendronic acid on skeletal-related events and bone metastasis from thyroid cancer

Orita et al., 201039

Retrospective cohort analysis

Determine prognostic factors and analyse treatment methods

Petrich et al., 200040

Retrospective cohort analysis

Determine the therapeutic outcome and side effects of radioiodine in bone metastasis from thyroid cancer

Pittas et al., 200030

Retrospective cohort analysis

Determine prognostic indicators and impact of treatment on survival

Quan et al., 201241

Retrospective cohort analysis

Determine survival of patients with vertebral metastasis from thyroid cancer

Qiu et al., 201142

Retrospective cohort analysis

Determine the efficacy of 131I therapy and survival

Schlumberger et al., 199643

Retrospective cohort analysis

Determine the response of bone and lung metastases to 131I

Stojadinovic et al., 200244

Retrospective cohort analysis

Determine distant disease free survival and post metastatic disease specific survival after surgery for distantly metastatic thyroid carcinoma

Van Tol et al., 200045

Retrospective cohort analysis

Determine the effect of embolisation in combination with radioiodine in terms of pain, serum T and neurological symptoms

Vitale et al., 200146

Retrospective cohort analysis

Determine the impact of pamidronate on bone pain, performance status and evaluate the degree of tumour response.

Wells et al., 201247

Phase III RCT

Determine progression free survival of patients on vandetanib for metastatic thyroid cancer

Zettinig et al., 200248

Retrospective cohort analysis

Determine the role of surgery on survival of metastatic thyroid cancer