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Table 1 Summary of the study characteristics

From: Spinal metastasis in thyroid cancer

Study, year Study design End point
Bernier et al., 200135 Retrospective cohort analysis Survival and impact of treatment on survival.
Cabanillas et al., 201036 Prospective intervention Determine response and progression free survival due to treatment with sorafenib/sunitinib
De Vries et al., 200837 Retrospective cohort analysis Determine the effect of selective embolisation on serum thyroglobulin and symptoms
Demura et al., 201114 Retrospective cohort analysis Determine the effect of total en bloc spondylectomy on survival and local recurrence
Durante et al., 200631 Retrospective cohort analysis Determine the response and effect on survival of 131I therapy
Eustatia-Rutten et al., 200317 Retrospective cohort analysis Determine the effect of palliative embolisation on clinical symptoms.
Hindie í et al., 200715 Observational study To investigate the impact of early 131I-based detection on outcome.
Kloos et al., 200938 Phase II Trial Objective response rate of VEGFR inhibitors
Orita et al., 201116 Retrospective cohort analysis Determine the efficacy of zolendronic acid on skeletal-related events and bone metastasis from thyroid cancer
Orita et al., 201039 Retrospective cohort analysis Determine prognostic factors and analyse treatment methods
Petrich et al., 200040 Retrospective cohort analysis Determine the therapeutic outcome and side effects of radioiodine in bone metastasis from thyroid cancer
Pittas et al., 200030 Retrospective cohort analysis Determine prognostic indicators and impact of treatment on survival
Quan et al., 201241 Retrospective cohort analysis Determine survival of patients with vertebral metastasis from thyroid cancer
Qiu et al., 201142 Retrospective cohort analysis Determine the efficacy of 131I therapy and survival
Schlumberger et al., 199643 Retrospective cohort analysis Determine the response of bone and lung metastases to 131I
Stojadinovic et al., 200244 Retrospective cohort analysis Determine distant disease free survival and post metastatic disease specific survival after surgery for distantly metastatic thyroid carcinoma
Van Tol et al., 200045 Retrospective cohort analysis Determine the effect of embolisation in combination with radioiodine in terms of pain, serum T and neurological symptoms
Vitale et al., 200146 Retrospective cohort analysis Determine the impact of pamidronate on bone pain, performance status and evaluate the degree of tumour response.
Wells et al., 201247 Phase III RCT Determine progression free survival of patients on vandetanib for metastatic thyroid cancer
Zettinig et al., 200248 Retrospective cohort analysis Determine the role of surgery on survival of metastatic thyroid cancer