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Table 3 Univariate and multivariate analysis of factors affecting local control

From: Definitive radiotherapy for early stage glottic cancer by 6 MV photons

T1N0 T2N0
Parameters Event/pts Uni-variate Multivariate analysis Event/pts Uni-variate Multivariate analysis
   P value Hazard ratio (95% CI) P value P value Hazard ratio (95% CI) P value
Age         
<61 18/142 0.302 - NS 22/90 0.747 - NS
61-70 15/153     23/103    
>70 9/138     13/69    
Sex         
Male 41/413 0.445 - NS 55/249 0.831 - NS
Female 1/20     3/13    
Substage         
T1A 28/324 0.24 - NS NA - - -
T1B 14/109        
Grade         
Well diff 9/154 0.0001* 1 0.035* 10/64 0.025* 1  
Moderate diff 29/273   1.91 (1.2- 3.85)   40/179   2.4 (1.7- 3.2) 0.022*
Poorly diff 4/6   7.5
(3.42- 5.24)
  8/19   4.3
(2.6- 8.9)
 
Impaired Cord mobility         
yes NA - - - 11/51 0.53 - NS
No      47/211    
Subglottic Extension         
Yes NA - - - 23/80 0.038* 2.15 (1.78-5.51) 0.027*
No      35/182   1  
Hb (g/dL)         
< 13.0 6/45 0.367 - NS 15/28 0.001* 3.78 (1.34-8.40) 0.031*
≥ 13.0 36/388     43/234   1  
AC         
No 14/236 0.004* 1 0.011* 12/76 0.129 - NS
Yes 28/197   2.34 (1.21-4.52)   46/186    
Field size (cm2)         
<30.5 35/215 0.534 - NS 0 0.138 - NS
30.5- 35.5 7/165     26/106    
> 35.5 0/53     32/156    
Dose size         
2.0 Gy 32/256 0.021* 2.17 (1.28- 4.18) 0.035* 45/176 0.042* - NS
2.5 Gy 10/177   1   13/86    
BEDGy15         
< 65.0 36/315 0.025* 3.38 (1.29- 7.83) 0.017* 12/76 0.022* 1.8 (1.2- 5.74) 0.038*
≥ 65.0 6/118   1   46/186   1  
Tx period         
1983- 1990 10/115 0.643 - NS 17/75 0.336 - NS
1991- 2000 25/224     29/142    
2001- 2005 7/94     12/45    
  1. Abbreviations: pts = patients; Hb = hemoglobin; Tx = treatment; diff = differentiated; AC = anterior commissure; BED = biologically effective dose; * = statistically significant; NS = not significant.