Head & Neck Oncology

Table 3 Univariate and multivariate analysis of factors affecting local control

From: Definitive radiotherapy for early stage glottic cancer by 6 MV photons

T1N0					T2N0
Parameters	Event/pts	Uni-variate	Multivariate analysis		Event/pts	Uni-variate	Multivariate analysis
		P value	Hazard ratio (95% CI)	P value	Event/pts	P value	Hazard ratio (95% CI)	P value
Age
<61	18/142	0.302	-	NS	22/90	0.747	-	NS
61-70	15/153				23/103
>70	9/138				13/69
Sex
Male	41/413	0.445	-	NS	55/249	0.831	-	NS
Female	1/20				3/13
Substage
T1A	28/324	0.24	-	NS	NA	-	-	-
T1B	14/109
Grade
Well diff	9/154	0.0001*	1	0.035*	10/64	0.025*	1
Moderate diff	29/273		1.91 (1.2- 3.85)		40/179		2.4 (1.7- 3.2)	0.022*
Poorly diff	4/6		7.5 (3.42- 5.24)		8/19		4.3 (2.6- 8.9)
Impaired Cord mobility
yes	NA	-	-	-	11/51	0.53	-	NS
No					47/211
Subglottic Extension
Yes	NA	-	-	-	23/80	0.038*	2.15 (1.78-5.51)	0.027*
No					35/182		1
Hb (g/dL)
< 13.0	6/45	0.367	-	NS	15/28	0.001*	3.78 (1.34-8.40)	0.031*
≥ 13.0	36/388				43/234		1
AC
No	14/236	0.004*	1	0.011*	12/76	0.129	-	NS
Yes	28/197		2.34 (1.21-4.52)		46/186
Field size (cm²)
<30.5	35/215	0.534	-	NS	0	0.138	-	NS
30.5- 35.5	7/165				26/106
> 35.5	0/53				32/156
Dose size
2.0 Gy	32/256	0.021*	2.17 (1.28- 4.18)	0.035*	45/176	0.042*	-	NS
2.5 Gy	10/177		1		13/86
BEDGy₁₅
< 65.0	36/315	0.025*	3.38 (1.29- 7.83)	0.017*	12/76	0.022*	1.8 (1.2- 5.74)	0.038*
≥ 65.0	6/118		1		46/186		1
Tx period
1983- 1990	10/115	0.643	-	NS	17/75	0.336	-	NS
1991- 2000	25/224				29/142
2001- 2005	7/94				12/45

Abbreviations: pts = patients; Hb = hemoglobin; Tx = treatment; diff = differentiated; AC = anterior commissure; BED = biologically effective dose; * = statistically significant; NS = not significant.

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