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Table 1 Studies of single agents in ACC, MEC and ADC of salivary glands

From: Systemic therapy in the management of metastatic or advanced salivary gland cancers

Treatment

ACC

MEC

ADC

Author

Regimen

Nb of patients

Nb of objective responses

Nb of patients

Nb of objective responses

Nb of patients

Nb of objective responses

Licitra et al 7

Cisplatin 100 mg/m² every 3w

13

2

5

1

5

0

DeHann et al 9

Cisplatin 50–120 mg/m² every 4w

10

0

-

-

-

-

Suen et al 13

Cisplatin

14

9

-

-

-

-

Kaplan et al 14

Cisplatin 100 mg/m²

17

10

-

-

-

-

Jones et al 40

Cisplatin 100 mg/m²

2

0

2

1

3

0

Schramm et al 8

Cisplatin 80-100 mg/m² every 4–6 w

10

7

-

-

-

-

Mattox et al 10

Mitoxantrone 12 mg/m² every 3w

18

1

-

-

-

-

Verweij et al 11

Mitoxantrone 14 mg/m² every 3w

32

4

-

-

-

-

Vermoken et al 12

Epirubicin 30 mg/m² weekly, if no response, 90 mg/m² every 3 w.

20

2

-

-

-

-

Suen et al 13 , Kaplan et al 14

Doxorubicin (various schema)

7

3

-

-

-

-

Airoldi et al 15

Vinorelbine 30 mg/m² weekly

13

2

-

-

5

2

Spiers et al 16 Tannock et al 17

Cyclophosphamide 100 mg/m² every 3 w

7

0

0

0

0

0

Tannock et al 17 , Suen et al 13 , Kaplan et al 14

5-Fluorouracil (various schema)

38

16

-

-

-

-

Tannock et al 17 , Suen et al 13 , Kaplan et al 14

Methotrexate (various schema)

10

0

5

2

1

0

Gilbert et al 18

Paclitaxel 200 mg/m² every 3 w.

14

0

14

3

17

5

Raguse et al 19

Docetaxel 100 mg/m² every 3 w

-

-

4

4

-

-

Van Herpen et al 21

Gemcitabine 1250 mg/m² d1 and d8 every 3 w.

21

0

-

-

-

-

  1. ACC = adenoid cyctic carcinoma, MEC = mucoepidermoid carcinoma, ADC = adenocarcinoma.