Skip to main content
Figure 1 | Head & Neck Oncology

Figure 1

From: Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line

Figure 1

Diagram detailing mechanism of HPV+ RIT with radiolabeled mAbs to intracellular antigens E6 and E7. Intracellular antigens E6 and E7 are released from cancer cells as a consequence of a cellular turnover in a fast-growing tumor. E6 or E7-specific mAbs bind to extracellular E6 and E7 and deliver cytotoxic radiation to the area. The viable tumor cells including those with no or weak E6 or E7 expression are killed by radiation through "cross-fire" effect by radiation emitted in 360° sphere.

Back to article page

Head & Neck Oncology

ISSN: 1758-3284