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Figure 1 | Head & Neck Oncology

Figure 1

From: Mammalian target of rapamycin and head and neck squamous cell carcinoma

Figure 1

Mammalian target of rapamycin is a key regulator in development and progression of cancer. Mammalian target of rapamycin responds to stimuli of growth factor, insulin, tobacco components, nutrients, hypoxia, ATP and RHEB to activate P70S6 and inhibit 4EBP1 and PP5 with subsequent dysregulation of apoptosis, cell survival, cell transformation, tumorigenesis, angiogenesis, invasion and metastasis. PI3K, phosphatidylinositol 3-kinase; ATP, adenosine triphosphate; RHEB, ras homologue enriched in brain; mTORC1, mammalian target of rapamycin complex 1; PP5, protein phosphatase 5; ASK1, apoptosis-signal-regulating kinase 1; p70S6, ribosomal p70 S6; EIF4E, eukaryotic translation initiation factor 4E; 4E-BP1, EIF4E-binding protein 1.

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