Specific TP53 mutations predict aggressive phenotype in head and neck squamous cell carcinoma: a retrospective archival study

Peltonen, Jenni K; Vähäkangas, Kirsi H; Helppi, Henni M; Bloigu, Risto; Pääkkö, Paavo; Turpeenniemi-Hujanen, Taina

doi:10.1186/1758-3284-3-20

Table 2 Features of the primary tumours regarding primary treatment regimen, follow up time and cause of death

From: Specific TP53 mutations predict aggressive phenotype in head and neck squamous cell carcinoma: a retrospective archival study

Tumour	Age	Disease site	Stage	TP53 gene status	Surgery	Radiation- therapy (radical)	Disease free in months	Overall survival in months	Death related to HNSCC
1	65	larynx	2	wild type	Yes	Yes	166	166	No
2	61	larynx	3	wild type	Yes	Yes	145	145	No
3	56	pharynx	3	mutation outside L2/L3/LSH motif	Yes	Yes	156	156	No
4	65	larynx	3	mutation outside L2/L3/LSH motif	Yes	Yes	121	121	No
5	48	pharynx	3	wild type	Yes	Yes		74	Yes
7	48	oral cavity	3	wild type	Yes	Yes	158	158	No
8	75	oral cavity	2	wild type	Yes	Yes	6	15	Yes
9	28	oral cavity	3	mutation outside L2/L3/LSH motif	Yes	Yes	155	155	No
10	58	oral cavity	3	wild type	Yes	Yes	11	8	Yes
12	78	oral cavity	2	mutation in L2/L3/LSH motif	Yes	No	7	40	Yes
13	83	larynx	2	wild-type	Yes	Yes	51	51	No
14	45	larynx	1	wild type	Yes	Yes	122	122	No
16	85	pharynx	3	mutation in L2/L3/LSH motif	Yes	Yes	32	32	No
17	74	oral cavity	3	wild type	Yes	No	3	12	Yes
18	72	larynx	1	mutation outside L2/L3/LSH motif	Yes	Yes	164	164	No
19	57	larynx	4	mutation outside L2/L3/LSH motif	Yes	Yes	24	24	No
20	62	oral cavity	3	mutation in L2/L3/LSH motif	No	only palliative	0	1	Yes
26	68	larynx	4	wild type	Yes	Yes	9	18	Yes
28	65	oral cavity	4	mutation in L2/L3/LSH motif	No	only palliative	6	22	Yes
29	33	oral cavity	3	mutation outside L2/L3/LSH motif	Yes	Yes	157	157	No
31	71	oral cavity	1	mutation in L2/L3/LSH motif	Yes	No	20	84	Yes
32	39	oral cavity	3	mutation in L2/L3/LSH motif	Yes	Yes	37	40	Yes
39	68	larynx	4	wild type p53	Yes	Yes	11	19	Yes
41	53	nose	2	wild type p53	Yes	Yes	7	18	Yes
43	74	larynx	2	mutation in L2/L3/LSH motif	No	Yes	154	154	No
45	70	pharynx	3	wild type p53	Yes	Yes	142	142	No
46	62	larynx	1	mutation outside L2/L3/LSH motif	Yes	Yes	135	135	No
49	62	oral cavity	1	mutation in SSCP	Yes	No	60	67	Yes
50	49	larynx	3	wild type p53	Yes	Yes	122	122	No
51	63	larynx	2	mutation outside L2/L3/LSH motif	Yes	Yes	109	109	No
52	63	larynx	4	wild type p53	Yes	Yes	20	30	Yes
53	74	oral cavity	4	mutation in L2/L3/LSH motif	Yes	No	35	37	Yes
54	42	larynx	3	mutation outside L2/L3/LSH motif	Yes	Yes	144	144	No
55	71	larynx	1	wild type p53	Yes	Yes	145	145	No
56	59	larynx	4	mutation in L2/L3/LSH motif	Yes	Yes	155	155	Yes
58	74	pharynx	4	mutation outside L2/L3/LSH motif	No	Yes	29	32	Yes
59	56	oral cavity	3	wild type p53	Yes	Yes	163	163	No
60	69	larynx	4	mutation in L2/L3/LSH motif	Yes	Yes	22	22	No
61	63	larynx	3	mutation in L2/L3/LSH motif	No	Yes	15	15	No
62	74	larynx	2	wild type p53	Yes	Yes	25	25	No
63	69	larynx	3	mutation in L2/L3/LSH motif	Yes	No	5	7	Yes
64	56	larynx	3	mutation in L2/L3/LSH motif	Yes	Yes	151	151	No
65	75	larynx	3	wild type p53	Yes	Yes	20	25	Yes
68	76	pharynx	4	SSCP positivity	No	only palliative	0	4	Yes
69	65	larynx	2	mutation outside L2/L3/LSH motif	No	Yes	12	43	Yes
70	68	sinonasal	4	wild type p53	Yes	Yes	160	160	No

Back to article page

Head & Neck Oncology