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Table 1 Modern methods of oral cytology for oral squamous cell carcinoma

From: Oral squamous cell cancer: early detection and the role of alcohol and smoking

Classification Analytic method Markers
Cytomorphometry Conventional cytologic diagnosis Cell morphology
  Computer-assisted image Cell morphology
  analysis (OralCDx)  
DNA analysis DNA image cytometry DNA ploidy, DNA methylation
Optical diagnosis Autofluorescence Flavin, tryptophan, elastin,
   collagen (endogenous fluorophores)
  Photodynamic diagnosis 5-Aminolevulinic acid
   Photofrin
  Immunophotodiagnosis antibody targeting EGFR