The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck

Chau, Nicole G; Perez-Ordonez, Bayardo; Zhang, Katherine; Pham, Nhu-An; Ho, James; Zhang, Tong; Ludkovski, Olga; Wang, Lisa; Chen, Eric X; Tsao, Ming-Sound; Kamel-Reid, Suzanne; Siu, Lillian L

doi:10.1186/1758-3284-3-11

Table 3 EGFRvIII mutation negative detected by RT-PCR (n = 19) and inconclusive cases (n = 12)

From: The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck

Case	Treatment	Primary Site	Specimen Site	EGFRvIII by RT-PCR	EGFRvIII Fold Changes	HPV DNA by Linear Array	P16 IHC	MET score by IHC	EGFR FISH
23	Erlotinib	larynx	Local recurrence	-	1.76	-	-	High	Low polysomy
24	Erlotinib	larynx	Untreated primary	-	0.95	-	-	NE	NE
25	Erlotinib	oropharynx	Untreated primary	Incon.	NE	16 +	-	Low	Failed
26	Erlotinib	larynx	Untreated	Incon.	NE	-	-	NE	NE
27	Erlotinib	oropharynx	Local recurrence	-	2.56	16 +	-	High	Failed
28	Erlotinib	neck mass unknown primary	Local recurrence	-	1.81	-	-	High	Low polysomy
29	Erlotinib	paranasal sinus	Untreated primary	-	0.56	-	-	High	High polysomy
30	Erlotinib	oropharynx	Untreated primary	-	3.16	16 +	+	High	Low trisomy
31	Erlotinib	larynx	Untreated primary	-	3.17	-	-	High	Low polysomy
32	Erlotinib	oropharynx	Local recurrence	NE	NE	-	+	Low	Low polysomy
33	Erlotinib	larynx	Untreated primary	-	3.16	-	-	High	High trisomy
34	Erlotinib + Cisplatin	oropharynx	Untreated primary	Incon.	NE	Incon.	+	Low	NE
35	Erlotinib + Cisplatin	larynx	Untreated primary	-	4.29	-	-	Low	Low polysomy
36	Erlotinib + Cisplatin	oral cavity	Untreated primary	-	0.9	-	-	Low	High polysomy
37	Erlotinib + Cisplatin	paransal sinus	Local recurrence	Incon.	NE	16+, 53+	Incon.	Low	Low polysomy
38	Erlotinib + Cisplatin	larynx	Local recurrence	Incon.	NE	16+, 53+, 33+, 51+	+	High	Disomy
39	Erlotinib + Cisplatin	paranasal sinus	Local recurrence	-	2.59	6+	-	High	NE
40	Erlotinib + Cisplatin	oral cavity	Untreated primary	-	2.01	-	-	High	Disomy
41	Erlotinib + Cisplatin	oropharynx	Untreated primary	Incon.	NE	-	+	High	Low trisomy
42	Erlotinib + Cisplatin	oral cavity	Untreated primary	Incon.	NE	-	-	High	High polysomy
43	Sorafenib	oral cavity	Untreated primary	Incon.	6.8	-	-	Low	Low polysomy
44	Sorafenib	oropharynx	Untreated primary	-	0.99	-	+	High	Amplification/High trisomy
45	Sorafenib	oral cavity	Local recurrence	Incon.	NE	Incon.	-	Low	Low polysomy
46	Sorafenib	oropharynx	Untreated primary	Incon.	6.22	16 +	+	Low	Low trisomy
47	Sorafenib	larynx	Local recurrence	-	2.28	-	+	High	High polysomy
48	Sorafenib	oropharynx	Untreated primary	-	0.64	-	-	High	Low polysomy
49	Sorafenib	oropharynx	Local recurrence	-	1.4	-	-	High	High polysomy
50	Sorafenib	oropharynx	Local recurrence	-	1.3	-	-	High	High polysomy
51	Sorafenib	oropharynx	Local recurrence	-	1.76	-	+	Low	Monosomy/Disomy
52	Ispinesib	oropharynx	Untreated lymph node	Incon.	NE	-	-	High	Low polysomy
53	Ispinesib	oropharynx	Node recurrence	-	4.05	16 +	-	Low	Amplification

Abbreviations: +, positive; -, negative; Incon., inconclusive; NE, not evaluable

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Head & Neck Oncology