Figure 2

Hematoxilin and eosin stained histologic sections from the original tumor. An invasive well-differentiated squamous cell carcinoma, the tumor is arranged as cohesive islands of cells showing nuclear pleomorphism with occasionally prominent nucleoli. Mitotic activity is present including atypical forms. In areas, abundant keratin production is present including whirling "keratin pearl" configurations. Intercellular bridges are visible at high power magnification. Surrounding the invasive tumor, a dense lymphoplasmacytic inflammatory infiltrate is present (A ×200, B ×400 original magnification).