From: p53 in head and neck cancer: Functional consequences and environmental implications of TP53mutations
Sample | Exon(s) | Muta-ted codon | Mutation by sequencing | AA change | Change in properties | Structural motif a | Protein function |
---|---|---|---|---|---|---|---|
H&N 12 | 5 5 7 | 130 139 225 | CTC>ATC AAG>TGG GTT > GCT | Leu > Ile Lys > Trp Val > Ala | no change +charged > aromatic hydrophobic > polar | LSH L L | NF ND F |
H&N 18 | 5 | 155 | ACC > AGCTGC | extra Cys | small | L | ND |
H&N 19 | 5 7 | 157 258 | GTC>TTC GAA > AAA | Val > Phe Glu > Lys | hydrophobic, small >aromatic, big -charge, acidic > +charge | S4 S9 | NFb NFb |
H&N 20 | 7 8 | 243 297 | ATG>CTG CAC > TAC | Met > Leu His > Tyr | Leu aliphatic no change | L3 (D) | NFb ND |
H&N 31 | 5 | 171 | GAG > GAC | Glu > Asp | big >small | L2 (S) | F |
H&N 29 | 7 | 259 | GAC > GAA | Asp > Glu | small > big | L | NFb |
H&N 32 | 5 8 | 171 271 | GAG>GAC GAG > TAG | Glu > Asp Glu > stop | big >small | L2 (S) S10 | F ND |
H&N 28 | 8 | 14496 | 16 bases deletion | Frameshift mutation | ND | ||
H&N 3 | 5 7 | 159 254 | GCC >ACC ATC > GTC | Ala >Thr Ile > Val | no change big > small | S4 S9 | Fb Fb |
H&N 16 | 5 7 | 130 245 | CTC>TTC GGC > GAC | Leu > Phe Gly > Asp | aliphatic > aromatic polar > acidic | LSH L3 (D) | NFb NFb |
H&N 4 | 5 8 | 184 283 | -1G CGC > CCC | Frameshift Arg >Pro | + charged > polar | H2 (LSH) (D) | NFb, d |
H&N 58 | 7 | 259 | GAC > GAA | Asp > Glu | small > big | L | NFb |
H&N 53 | 5 | 172 | GTT > GCT | Val > Ala | hydrophobic > polar | L2 (S) | Fb |
H&N 64 | 7 | 238 | TGT > TCT | Cys > Ser | hydrophobic > polar | L3 (D) | NFb |
H&N 63 | 6 | 189 | GCC > GTC | Ala > Val | polar > hydrophobic | L2 (S) | Fb |
H&N 51 | 7 | 259 | GAC > GAA | Asp > Glu | small > big | L | NFb |
H&N 54 | 7 | 259-260 | GACTCC > GATCCC | Asp, Ser > Asp, Pro | no change | L | NFd |
H&N 56 | 8 | 275 | TGT > TAT | Cys > Tyr | small > big, aromatic | LSH | NFb |
H&N 46 | 6 | 217 | GTG > GCG | Val > Ala | hydrophobic > polar | S7 | Fb |
H&N 43 | 5 | 155 175 | ACC>TCC CGC > CAC | Thr > Ser Arg > His | no change + charged > big, aromatic | L L2 (S) | Fb NF b, c |
H&N 61 | 5 | 171 | GAG > GAC | Glu > Asp | big >small | L2 (S) | F |
Sample | Exon(s) | Muta-ted codon | Mutation by sequencing | AA change | Change in properties | Structural motif a | Protein function |
H&N 60 | 5 7 | 172 259 | GTT>CTT GAC > GAA | Val > Leu Glu > Asp | small > big big >small | L2 (S) L | F NFb |
H&N 69 | 5 6 | 148 221 | GAT>GAG GAG > GAC | Asp > Glu Glu > Asp | small > big big >small | L L | Fb Fb |