Schematic of overall study design. The figure depicts the basic workflow algorithm involved in the design, synthesis and characterization of the nanoparticles for dual modality imaging. Following initial synthesis, characterization of the optical properties of Pt(TPNP)-Gd polymeric nanomicelles was performed using transmission electron microscopy, optical spectroscopy and dynamic light scattering techniques. MR relaxometric measurements were also performed in phantoms and compared to clinically approved MR contrast agents. Subsequently, in vivo studies were performed using patient tumor-derived human head and neck squamous cell carcinoma (HNSCC) xenografts to determine the potential of the polymeric nanomicelles for dual modality imaging.