From: Malignant head and neck paragangliomas: Is there an optimal treatment strategy?
Summary of tumor characteristics, treatment and responses | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Primary Site | Metastatic Sites | Treatment | Response | ||||||||||
Carotid Body | Jugulo-tympanic | Other | Liver | Lung | Bone | Other | Radiation | Chemotherapy | Both | Progression | Stable | Regression | |
By Gender | |||||||||||||
Men | 1 (17%) | 4 (67%) | 1 (17%) | 1 (17%) | - | 6 (100%) | 3 (50%) | 5 (83%) | 4 (67%) | 4 (67%) | 5 (83%) | 1 (17%) | - |
Women | 9 (69%) | 2 (15%) | 2 (15%) | 4 (31%) | 7 (54%) | 7 (54%) | 9 (69%) | 9 (69%) | 7 (54%) | 6 (46%) | 5 (38%) | 4 (31%) | 1 (8%) |
By Age at Presentation | |||||||||||||
> 40 | 3 (33%) | 3 (33%) | 3 (33%) | 2 (22%) | 4 (44%) | 6 (67%) | 6 (67%) | 7 (78%) | 5 (56%) | 5 (56%) | 7 (78%) | 1 (11%) | - |
< = 40 | 7 (70%) | 3 (30%) | - | 3 (33%) | 3 (33%) | 7 (78%) | 6 (60%) | 7 (70%) | 6 (60%) | 5 (50%) | 3 (30%) | 4 (40%) | 1 (10%) |
By Primary Site | |||||||||||||
Carotid Body | 10 | - | - | 3 (30%) | 5 (50%) | 6 (60%) | 8 (80%) | - | - | - | 3 (30%) | 3 (30%) | 1 (10%) |
Jugulotympanic | - | 6 | - | 2 (33%) | 1 (17%) | 5 (83%) | 3 (50%) | - | - | - | 5 (83%) | 1 (17%) | - |
Other | - | - | 3 | - | 1 (33%) | 2 (67%) | 1 (33%) | - | - | - | 2 (67%) | 1 (33%) | - |
By Treatment | |||||||||||||
Radiation | 7 (70%) | 6 (100%) | 1 (33%) | - | - | - | - | 14 | - | - | 12 (92%) | 1 (8%) | 0 (0%) |
Chemotherapy | 7 (70%) | 3 (50%) | 1 (33%) | - | - | - | - | - | 11 | - | 6 (55%) | 2 (18%) | 1 (9%) |
Both | 6 (60%) | 3 (50%) | 1 (33%) | - | - | - | - | - | - | 10 | 6 (60%) | 2 (20%) | 1 (10%) |