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Table 5 Meta-analyses of association between p53 mutations, p16 and HPV

From: Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)

   Before outlier exclusion After outlier exclusion
Outcome Marker No. of Studies Adjusted OR (95% CI) No. of Studies Adjusted OR (95% CI)
HPV positive p53 (mutated) 4 0.21(0.04-0.38) 4 0.21(0.04-0.38)
      P = 0.015
HPV positive p16 2 5.02(1.08-8.97) 1 3.00(0.90-9.70)
  IHC     p = 0.181