Head & Neck Oncology

Table 3 Association of HPV status with gender, age, tumor stage, alcohol and tobacco consumption

From: Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)

Demographic	# Studies	HPV status	Smoking status	N	%
Tobacco	17	HPV+	Ever	1068	55.9
			Never	948	44.1
		HPV-	Ever	2179	74.5
			Never	677	25.5
Ethanol	16	HPV+	Ever	1548	66.8
			Never	768	33.2
		HPV-	Ever	2186	75.4
			Never	713	24.6
Stage	10*	HPV+	I-II	78	26.7
			III-IV	214	73.3
		HPV-	I-II	259	42.8
			III-IV	346	57.2
LN Stage	6	HPV+	N0	45	33.5
			N1-N3	123	66.5
		HPV-	N0	204	45.9
			N1-N3	240	54.1
Gender	18	HPV+	M	1525	67.8
			F	724	32.2
		HPV-	M	2010	66.1
			F	1033	33.9
Median Age	5**	HPV+	55 years
		HPV-	60 years

HPV: human papillomavirus; M: male; F: female; LN, lymph node; * 2 studies compared stage I-III vs. stage IV; ** 5 studies reported the median age of the subjects.

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