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Table 3 Association of HPV status with gender, age, tumor stage, alcohol and tobacco consumption

From: Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)

Demographic # Studies HPV status Smoking status N %
Tobacco 17 HPV+ Ever 1068 55.9
    Never 948 44.1
   HPV- Ever 2179 74.5
    Never 677 25.5
Ethanol 16 HPV+ Ever 1548 66.8
    Never 768 33.2
   HPV- Ever 2186 75.4
    Never 713 24.6
Stage 10* HPV+ I-II 78 26.7
    III-IV 214 73.3
   HPV- I-II 259 42.8
    III-IV 346 57.2
LN Stage 6 HPV+ N0 45 33.5
    N1-N3 123 66.5
   HPV- N0 204 45.9
    N1-N3 240 54.1
Gender 18 HPV+ M 1525 67.8
    F 724 32.2
   HPV- M 2010 66.1
    F 1033 33.9
Median Age 5** HPV+ 55 years   
   HPV- 60 years   
  1. HPV: human papillomavirus; M: male; F: female; LN, lymph node; * 2 studies compared stage I-III vs. stage IV; ** 5 studies reported the median age of the subjects.