|
Drug
|
Enhanced anti-tumor effect in vivo1
|
Reference2
|
|---|
|
Cisplatin
|
Yes – Oral cancer
|
[38]
|
|
Cyclophosphamide
|
Yes – Oral cancer
|
[42]
|
|
Estrogen
|
No
|
[45]
|
|
5-FU
|
No
|
[40]
|
|
Gemcitabine
|
No
|
[40]
|
|
Hexamethylene bisacetamide
|
Yes – Oral cancer
|
[43]
|
|
Mitomycin C
|
Yes – Gastric cancer
|
[46]
|
|
N-acetylcysteine
|
No
|
[44]
|
|
Trichostatin A
|
No
|
[41]
|
|
Vincristine
|
Yes – Rhabdomyosarcoma
|
[39]
|
- 1 Although each of the drugs shown here has been found to increase the growth-inhibiting effects of adenovirus or HSV-1-vectors in cell culture, only some have been shown to increase the anti-tumor effect in animal models.
- 2 Only one representative reference is shown for each drug, although other laboratories have reported similar findings in many cases.
