Gene therapy: the end of the rainbow?

Head & Neck Oncology

Table 1 Drugs that increase the effects of oncolytic viruses

Drug	Enhanced anti-tumor effect in vivo¹	Reference²
Cisplatin	Yes – Oral cancer	[38]
Cyclophosphamide	Yes – Oral cancer	[42]
Estrogen	No	[45]
5-FU	No	[40]
Gemcitabine	No	[40]
Hexamethylene bisacetamide	Yes – Oral cancer	[43]
Mitomycin C	Yes – Gastric cancer	[46]
N-acetylcysteine	No	[44]
Trichostatin A	No	[41]
Vincristine	Yes – Rhabdomyosarcoma	[39]

¹ Although each of the drugs shown here has been found to increase the growth-inhibiting effects of adenovirus or HSV-1-vectors in cell culture, only some have been shown to increase the anti-tumor effect in animal models.
² Only one representative reference is shown for each drug, although other laboratories have reported similar findings in many cases.