Figure 1

An innocuous appearing submucosal nodule (arrow) was noted on the posterior hard palate of a 59-year-old white female during standard clinical examination which upon examination with a multispectral oral cancer screening device (Identafi™ 3000), revealed loss of autofluorescence. A: White light image of the metastatic lesion; B: Fluorescence image at 405 nm illumination; C: Microscopic examination of the biopsy revealed the presence of metastatic squamous carcinoma, Bar = 100 μM (C). In comparison, a similar appearing benign fibroma (arrow) exhibits normal autofluorescence. D: White light image of a benign fibroma; E: Fluorescence image at 405 nm illumination; F: Microscopic examination of the biopsy revealed reactive fibrous hyperplasia, Bar = 100 μM.