Role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review

Table 2 Prevalence of HPV identification in premalignant lesions of Head and Neck

Study	Year	Positive/cases	%	Lesion Type	Mode of Detection
Zeuss et al [87]	1991	0/20	0	Dysplasia	ISH 6/11, 16/18, 31/33/35
Holladay & Gerald [88]	1993	13/45	28.9	Dysplasia, inflammation hyperplasia	E1 PCR
Fouret et al [89]	1995	0/3	0	Dysplasia	E6 consensus PCR
Nielsen et al [90]	1996	20/49	40.8	Dysplasia leukoplakias	ISH/HPV 16 PCR, SB PCR
Wen et al [91]	1997	5/17	29.4	Papilloma, leukoplakias, OLP	E6 HPV 16/18 PCR
D'Costa et al [70]	1998	27/80	33.8	Leukoplakias, OLP, OSMF	L1 consensus PCR
Bouda et al [26]	2000	29/34	85.2	Hyperplasia dysplasia	Nested consensus PCR
Ha et al [21]	2002	1/102	1.0	Dysplasia	Quantitative PCR
Ostwald et al [64]	2003	72/118	22.2	Oral Leukoplakia	PCR/Southern blot hybridization
		65/118	15.4	OLP
Lo Muzio et al [92]	2004	6/7	85.7	Oral leukoplakia	Nested PCR, IHC
Campisi et al [65]	2004	68/139	17.6	Oral Leukoplakia	PCR
		71/139	19.7	OLP
Chen et al [67]	2006	12/23	52.6	OSMF	PCR
Furrer et al [63]	2006	9/22	41	Potentially malignant and malignant head and neck lesions	PCR- Southern Blot
Giovannelli et al [93]	2006	50/116	22	Oral leukoplakia	PCR
Bagan et al [62]	2007	0/13	0	Proliferative verrucous leukoplakia	PCR
Luo et al [66]	2007	14/46	30.4	Pre-cancerous lesion	Nested PCR, gene-chip arrays