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Table 1 Univariate analysis for local control, loco-regional control & disease free survival

From: Radical radiotherapy with concurrent weekly cisplatin in loco-regionally advanced squamous cell carcinoma of the head and neck: a single-institution experience

Prognostic factor Patients 5-yr LC p-value 5-yr LRC p-value 5-yr DFS p-value
Age        
   > 54 yrs 110 46.8% 0.057 36.2% 0.067 35.0% 0.123
   ≤ 54 yrs 154 65.1%   53.6%   49.0%  
HP Grade        
   NOS 232 55.2% 0.115 44.2% 0.153 41.8% 0.241
   WD 04 33.3%   33.0%   33.3%  
   MD 05 80.0%   40.0%   40.0%  
   PD 23 73.7%   64.2%   55.2%  
T stage        
   T1-T2 53 73% 0.004 43.4% 0.079 36.1% 0.078
   T3 153 59%   50.7%   49.3%  
   T4 58 50%   36%   33.8%  
N stage        
   N0 64 66.0% 0.212 66.0% 0.001 66.0% 0.001
   N1 61 58.1%   54.1%   54.1%  
   N2-3 139 51.9%   31.9%   27.0%  
Stage Group        
   III 96 68.8% 0.005 66.1% 0.001 66.1% 0.001
   IV 168 50.3%   34.0%   29.7%  
Primary site        
   Oral cavity 18 13.9% 0.001 13.9% 0.012 13.9% 0.026
   Oropharynx 118 58.6%   50.7%   47.7%  
   Hypopharynx 93 59.3%   45.0%   42.9%  
   Larynx 35 71.9   50.2%   44.4%  
RT dose        
   < 70 Gy 51 51.2% 0.280 37.4% 0.125 35.9% 0.142
   ≥ 70 Gy 213 60.2%   50.5%   45.6%  
CT cycles        
   1–5 96 41.8% 0.022 26.8% 0.009 25.8% 0.011
   ≥ 6 168 64.5%   54.4%   49.6%  
KPS        
   < 80 51 46.4% 0.215 33.0% 0.183 30.3% 0.133
   ≥ 80 213 60.1%   49.3%   82.2%  
OTT        
   ≤ 51 days 116 67.7% 0.029 59.9% 0.013 56.5% 0.016
   > 51 days 97 51.1%   39.3%   35.5%  
  1. LC = local control; LRC = loco-regional control; DFS = disease free survival; NOS = not otherwise specified; WD = well differentiated; MD = moderately differentiated; PD = poorly differentiated; RT = radiotherapy; CT = chemotherapy; KPS = Karnofsky Performance Status; OTT = overall treatment time