Head & Neck Oncology

Table 4 Selected up-regulated genes identified in USC-HN1 cells by microarray analysis also present in HNSCC tumor biopsies.*

From: Establishment and Characterization of a Novel Head and Neck Squamous Cell Carcinoma Cell Line USC-HN1

GeneBank Access ID	Gene Symbol & Annotation	Log2 Fold Difference**
*Immune Response*
L19686	MIF, macrophage migration inhibitory factor	3.1
NM_002116	HLA-A, major histocompatibility complex, class I A	2.2
X16302	IGFBP2, insulin-like growth factor binding protein 2	1.7
L33930	CD24, CD24 antigen	1.1
*Cell Growth, Maintenance/Cell cycle Regulation*
M26326	KRT18, keratin 18	6.2
NM_002273	KRT8, keratin 8	5.8
X95404	CFL1, cofilin 1	4.1
NM_005022	PFN1, profilin 1	4.0
Y00503	KRT19, keratin 19	3.6
AL031670	FTL, ferritin, light polypeptide	3.2
AF026291	CCT4, chaperonin subunit 4	3.2
NM_004360	CDH1, E-cadherin	2.3
*Translation and Protein Synthesis*
AK001313	RPLP0, ribosomal protein LP0	6.3
L11566	RPL18, ribosomal protein L18	5.5
M64241	RPL10, ribosomal protein L10	5.2
X69150	RPS18, ribosomal protein S18	4.9
U73824	EIF4G2, translation initiation factor 4 gamma 2	4.2
L06499	RPL37A, ribosomal protein L37A	4.0
M84711	RPS 3A, ribosomal protein S3A	3.8
U25789	RPL21, ribosomal protein L21	3.7
AL117412	EIF4A2, eukaryotic translation initiation factor 4A	2.9
Z21507	EEF1D, eukaryotic translation elongation factor 1D	1.2
*Metabolism*
M26252	PKM2, pyruvate kinase, muscle	5.7
NM_021130	PPIA, peptidylprolyl isomerase A (cyclophilin A)	4.7
X13794	LDHB, lactate dehydrogenase B	4.4
Z23090	HSPB1, heat shock 27 kDa protein	4.2
Y13936	PPM1G, protein phosphatase 1G	2.8
U09813	ATP5G3, ATP synthase H+ transporting subunit	2.7
AF061735	ATP5H, ATP synthase H+ transporting subunit	2.5
D29011	PSMB5, proteasome subunit, beta 5	2.4
Y00483	GPX1, glutathione peroxidase 1	2.3
M60483	PPP2CA, protein phosphatase 2 catalytic subunit	2.2
NM_001679	ATP1B3, ATP synthase Na+/K+ transporting, beta 3	1.6
M94856	FABP5, fat acid binding protein 5	1.2
*Ion Binding Proteins*
D38583	S100A11, S100 calcium binding protein A11	1.8
NM_020672	S100A14, S100 calcium binding protein A14	1.0
*Others*
S54005	TMSB10, thymosin, beta 10	4.2
M14328	ENO1, enolase 1	4.0
M26880	UBC, ubiquitin C	3.4
X67951	PRDX1, peroxiredoxin 1	3.2
M36981	NME2, non-metastatic cells 2 protein	3.1
NM_006016	CD164, CD164 antigen	2.6

*All selected genes with p-value < 0.05.
**Log2 ratio fold-differences between USC-HN1 cells and normal tonsil tissues were determined by subtracting the ratio of genes in normal tonsil tissue versus uRNA from the ratio of genes in USC-HN1 cells versus uRNA. (Log2 ratio of 1 equals to 2-fold difference between USC-HN1 cells and normal tissue; Log2 ratio of 2 equals to 4-fold difference between USC-HN1 and normal tissue, and so on).

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