Skull base approaches in neurosurgery
© Scholz et al; licensee BioMed Central Ltd. 2010
Received: 18 May 2010
Accepted: 5 July 2010
Published: 5 July 2010
The skull base surgery is one of the most demanding surgeries. There are different structures that can be injured easily, by operating in the skull base. It is very important for the neurosurgeon to choose the right approach in order to reach the lesion without harming the other intact structures. Due to the pioneering work of Cushing, Hirsch, Yasargil, Krause, Dandy and other dedicated neurosurgeons, it is possible to address the tumor and other lesions in the anterior, the mid-line and the posterior cranial base. With the transsphenoidal, the frontolateral, the pterional and the lateral suboccipital approach nearly every region of the skull base is exposable.
In the current state many different skull base approaches are described for various neurosurgical diseases during the last 20 years. The selection of an approach may differ from country to country, e.g., in the United States orbitozygomaticotomy for special lesions of the anterior skull base or petrosectomy for clivus meningiomas, are found more frequently than in Europe.
The reason for writing the review was the question: Are there keyhole approaches with which someone can deal with a vast variety of lesions in the neurosurgical field?
In my opinion the different surgical approaches mentioned above cover almost 95% of all skull base tumors and lesions. In the following text these approaches will be described.
These approaches are:
1) pterional approach
2) frontolateral approach
3) transsphenoidal approach
4) suboccipital lateral approach
These approaches can be extended and combined with each other. In the following we want to enhance this philosophy.
Ad 1) pterional approach
In the 1970 s Yasargil [1, 2] laid to the foundation of the pterional approach. The pterional approach allows the surgeon to address the circle of Willis and also pathological changes in the cavernous sinus area. In the 1960s Parkinson [3, 4] championed a route that exposed the cavernous sinus with less retraction of the brain then earlier approaches. The pterional approach is the standard surgical treatment for aneurysms in the anterior circle of Willis. During the Cushing era the term "nole mi tangere" ("don't touch me") was a rule for neurological surgeons, which considered treating intracranial aneurysms. The forefathers of aneurysm surgery were Norman Dott  and Walter Dandy . Dott reported the first surgical treatment of an intracranial aneurysm. His patient suffered from an aneurismal subarachnoid hemorrhage. Dandy  was the first to begin clipping aneurysms of the internal carotid artery. Tönnis  was one of the first to treat aneurysms in the circle of Willis. While Tönnis' route through the anterior part of the corpus callosum showed successful results, his first try to expose the aneurysm of the anterior communication artery by a subfrontal approach did not succeed.
Yasargil also described a technique that allows access to the same area: his skin incision is done until the temporal fascia is reached. He then creates a triangular galea flap and seperates the muscle after additional horizontal incision in order to protect the frontal branch of the facial Nerve. In our opinion the rate of nerve injury is minimal also if one is using the first technique. The advantage of the Yasargil Technique can be seen if one wants to combine the pterional approach with the subfrontal approach. The muscle can be retracted much easier downwards with this technique. In my opinion the rate of atrophic changes of the temporal muscle postoperatively is a little bit higher. We are using Palacaos to fill the burr holes. Other authors are using selected bone dust.
Case report 1
A 51-year-old man underwent an operation for a craniopharyngioma, through a pterional approach from the right side six months before. He was presented with a pituitary infarction. He has been treated with Testosterone (Testogel), Desmopressin (Minirin) and Hydrocortisone. He suffered from a progressive visual disturbance (visual acuity r 0.6, l 0.8) for 8 weeks. A bitemporal hemianopsia was diagnosed.
Case report 2
There were normal findings post-operatively with occasional diplopia, while the wound was healing per primam. Pathology revealed a meningothelial tumor of WHO grade I.
Case report 3
66-year-old patient, presented with a history of six seizures, suffers from a known retrochiasmal lesion with a growth in the MRI examinations.
There were no neurological deficits and the healing of the wound was by first intention. In contrast the patient showed fluctuating vigilambulism with nausea, vertigo and electrolyte imbalance. The patient was prescribed a long-term hydrocortisone substitution and Desmopressin (Minirin) for a short period of time.
Ad 2) frontolateral approach
The frontolateral or unilateral subfrontal approach provides exposure of the anterior cranial base. It allows addressing olfactory groove meningiomas (OGMs) by a minimally invasive procedure and it is also one of the traditionally used approaches on OGMs [9, 10]. Francesco Durante  marks the beginning of OGM extirpation. It was not until Fedor Krause , who used the unilateral subfrontal approach the first time to expose the sellar region. In contrast to Krause's tremendous impact on anterior fossa approach, Durante removed an OGM in 1885 via a transpalatine approach through an extension into the nasal fossae.
Case report 4
A 47-year-old patient with bitemporal hemianopsia and a 6-weeks history of progredient headache was presented. The patient manifested no further neurological deficits.
The further course was without any complications and the wound healing was per primam.
Visual field defects were on the decrease. Furthermore, we couldn't recognize any hormonal failure.
Ad3) transsphenoidal approach
The transsphenoidal route was first used by the Egyptians in order to remove the brain. The pioneering work of Harvey Cushing  and Oskar Hirsch  led to one of the most efficient ways to operate in the sellar region. Cushing advocated the approach sublabially and Hirsch accessed the sellar region endonasally. Before Cushing and Hirsch led to the milestone in pituitary gland surgery, Sir Victor Horsley  was the first to operate on the pituitary gland. While the minimally invasive surgery trend is set in motion nowadays, the contemporary neurosurgeons would call Sir Horsley's approach too radical. His route required the retraction of the frontal lobe. In 1898 D. Giordano  developed the fundamental concepts to expose the pituitary gland via a transnasal-frontoethmoidal approach. But the contemporary standard route to the pituitary gland is carried out through the transsphenoidal approach.
Ad 4) suboccipital lateral approach
The posterior cranial base can be explored through the lateral suboccipital route. Processes in the posterior fossa such as acoustic neurinoma surgery can be carried out through the lateral suboccipital approach. The unilateral suboccipital approach was popularized by Woolsey (1903) and with great contributions by Krause (1905) [21, 22]. After several refinements and modifications through different dedicated neurosurgeons (Fish , House [24, 25] and Seiffert ), Dandy's  suboccipital approach (1917) with an ipsilateral suboccipital flap evolved to what we call retrosigmoid transmeatal approach now. Cushing (1917)  on the other hand described a bilateral suboccipital access and stated the unilateral suboccipital approach as disadvantageous. In modern neurosurgery Majid Samii [29, 30] is considered to be one of the leading experts in vestibular nerve schwannoma surgery.
Attention should be paid to the variable emissary veins, which lead to the sigmoid sinus. First the dura should be opened under microscopic magnification in a triangular shape in the region of the pars horizontalis to gain cerebrospinal fluid and in order to relax the cerebellum.
Then the dura has to be opened near the sinus via a curved skin incision that connects with the previous dural opening.
By applying the transsphenoidal, the unilateral subfrontal, pterional and lateral suboccipital approach, the surgeon can expose almost any skull base involvement. The diameters of exposure can be modified by combining different approaches. The introduction of microsurgical techniques in the 1960 s [31, 32] is portrayed as a fundamental reason for the subsequently arising development in skull base surgery and the evolution of the approaches.
Complex pathologies at the skull base may need tailored approaches, which mainly have the base on one of the mentioned techniques. Extension of approaches can also be done in an interdisciplinary fashion with colleagues from other faculties like ENT or maxillofacical surgery, which is recommended by the author. While ENT can help accessing the skull base, e.g., in acoustic neuroma surgery  or by the help of an endoscope transnasally, maxillofacial surgery offers the wide spectrum of approaches through the oral cavity and maxilla.
A written informed consent was obtained from the patients for publication of the case reports and accompanying images. Copies of the written consents are available for review by the Editor-in-Chief of this journal.
- Krayenbuhl HA, Yasargil MG, Flamm ES, Tew JM: Microsurgical treatment of intracranial saccular aneurysms. J Neurosurg. 1972, 37: 678-86. 10.3171/jns.1972.37.6.0678.View ArticlePubMedGoogle Scholar
- Yasargil MG, Antic J, Laciga R, Jain KK, Hodosh RM, Smith RD: Microsurgical pterional approach to aneurysms of the basilar bifurcation. Surg Neurol. 1976, 6: 83-91.PubMedGoogle Scholar
- Parkinson D: A surgical approach to the cavernous portion of the carotid artery: anatomical studies and case report. J Neurosurg. 1965, 23: 474-483. 10.3171/jns.1965.23.5.0474.View ArticlePubMedGoogle Scholar
- Parkinson D: Transcavernous repair of carotid cavernous fistula. Case report. J Neurosurg. 1967, 26: 420-424. 10.3171/jns.1967.26.4.0420.View ArticlePubMedGoogle Scholar
- Dott NM: Intracranial aneurysms cerebral arterio-radiography and surgical treatment. Edinb Med J. 1933, 40: 219-34.Google Scholar
- Dandy WE: Intracranial arterial aneurysms. 1944, Ithaca, NY: Comstock PublishingGoogle Scholar
- Dandy WE: The surgical treatment of intracranial aneurysms of the internal carotid artery. Ann Surg. 1941, 114: 336-340. 10.1097/00000658-194109000-00003.PubMed CentralView ArticlePubMedGoogle Scholar
- Tönnis W: Traumatischer Aneurysma der linken Art. carotis int mit Embolie der linken Art. cerebri ant. und retinae. Zentrabl f Chir. 1934, 61: 844-848.Google Scholar
- Samii M, Ammirati M: Olfactory groove meningiomas. Surgery of the Skull Base: Meningiomas. Edited by: Samii M. 1992, Springer, Berlin, 15-25.View ArticleGoogle Scholar
- Spektor S, Valarezo J, Fliss DM, Gil Z, Cohen J, Goldman J, Umansky F: Olfactory groove meningiomas from neurosurgical and ENT perspectives: approaches, techniques, and outcomes. Neurosurgery 57: Operative Neurosurgery Supplement. 4: 268-280.
- Durante F: Contribution to endocranial surgery. Lancet. 1887, 2: 654-655. 10.1016/S0140-6736(02)10289-3.View ArticleGoogle Scholar
- Krause F: Chirurgie des Gehirns und Rückenmarks nach eigenen Erfahrungen. 1908, Berlin, Urban & Schwarzenberg, 1:Google Scholar
- Perneczky A, Muller-Forell W, van Lindert E: Keyhole Concept in Neurosurgery: With Endoscope-Assisted Microneurosurgery and Case Studies, New York: Thieme. 1999Google Scholar
- Van Lindert E, Perneczky A, Fries G, Pierangeli E: The supraorbital keyhole approachto supratentorial aneurysms: concept and technique. Surg Neurol. 1998, 49: 481-490. 10.1016/S0090-3019(96)00539-3.View ArticlePubMedGoogle Scholar
- Cushing H: Partial hypophysectomy for acromegaly: With remarks on the function of the hypophysis. Ann Surg. 1909, 50: 1002-10.1097/00000658-190912000-00003.PubMed CentralView ArticlePubMedGoogle Scholar
- Hirsch O: Symptoms and treatment of pituitary tumors. Arch Otolaryngol. 1952, 55: 268-View ArticleGoogle Scholar
- Horsley V: On the technique of operations on the central nervous system. BMJ. 1906, 2: 411-423. 10.1136/bmj.2.2382.411.PubMed CentralView ArticleGoogle Scholar
- Guidetti B, Giuffrè R, Valente V: Italian contribution to the origin of neurosurgery. Surg Neurol. 1983, 335-46. 10.1016/0090-3019(83)90091-5. 20:
- Honegger J, Buchfelder M, Fahlbusch R, Daubler B, Dorr HG: Transsphenoidal microsurgery for craniopharyngioma. Surg Neurol. 1992, 37: 189-196. 10.1016/0090-3019(92)90229-G.View ArticlePubMedGoogle Scholar
- Honegger J, Fahlbusch R, Buchfelder M, Huk WJ, Thierauf P: The role of transsphenoidal microsurgery in the management of sellar and parasellar meningioma. Surg Neurol. 1993, 39: 18-24. 10.1016/0090-3019(93)90104-9.View ArticlePubMedGoogle Scholar
- Krause F: Zur Freilegung der hinteren Felsenbeinfl228;che und des Kleinhirns. Beitr Klein Chir. 1903, 37: 728-764.Google Scholar
- Krause F: Surgery of the Brain and Spinal Cord. 1911, Rebmann, New York, II: 3-32.Google Scholar
- Fisch U: Chirurgie im inneren Gehörgang und an benachbarten Strukturen. Kopf und Hals-Chirurgie. Edited by: Naumann HH. 1976, Thieme, Stuttgart, New York, 3: 457-543.Google Scholar
- House WF: Transtemporal bone microsurgical removal of acoustic neuromas. Arch Otolaryngol. 1964, 80: 597-756.Google Scholar
- House WF: Surgical exposure of the internal auditory canal and its contents through the middle cranial fossa. Laryngoscope. 1961, 71: 1363-1385. 10.1288/00005537-196111000-00004.View ArticlePubMedGoogle Scholar
- Seiffert A: Zur Operation der Akustikusneurinome. Z Hals-Nase-Ohrenheilkd. 1937, 42: 237-239.Google Scholar
- Dandy WE: Results of removal of acoustic tumors by the unilateral approach. AMA Arch Surg. 1941, 42: 1026-1033.View ArticleGoogle Scholar
- Cushing H: Tumors of the Nervus Acusticus and the Syndrome of the Cerebellopontine Angle. 1917, Philadelphia: SaundersGoogle Scholar
- Samii M, Matthies C: Management of 1000 vestibular schwannomas (acoustic neuromas): surgical management and results with an emphasis on complications and how to avoid them. Neurosurgery. 1997, 40: 11-23. 10.1097/00006123-199701000-00002.PubMedGoogle Scholar
- Samii M, Draf W: Surgery of the internal auditory canal and cerebellopontine angle. Surgery of the Skull Base. An Interdisciplinary Approach. Edited by: Samii M, Draf W. 1989, Springer, Berlin Heidelberg, 360-409.View ArticleGoogle Scholar
- Yasargil MG, Fox JL, Ray MW: The operative approach to aneurysms of the anterior communicating artery. Advances and Technical Standards in Neurosurgery. Edited by: Krayenbühl H. 1975, Vienna, Springer Verlag, 2: 113-170.Google Scholar
- Kurze T: Microtechniques in neurological surgery. Clin Neurosurg. 1964, 11: 128-137.PubMedGoogle Scholar
- Tonn J-C, Schlake H-P, Goldbrunner R, Milewski C, Helms J, Roosen K: Acoustic neuroma surgery as an interdisciplinary approach: a neurosurgical series of 508 patients. J Neurol Neurosurg Psychiatry. 2000, 69: 161-166. 10.1136/jnnp.69.2.161.PubMed CentralView ArticlePubMedGoogle Scholar
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